Atypical Erythema Multiforme, a Clinical Mimicker of Monkeypox

Erythema multiforme (EM) is a skin eruption caused by a variety of triggers and may be misdiagnosed. Infection, most commonly with herpes simplex virus, has been linked to the development of EM. Mycoplasma pneumoniae is a rare but known cause in adults. Classically described as target lesions, atypical EM lacks the concentric areas of circular erythema bordered by clear zones. We present a case of atypical EM in a 71-year-old man with acute Mycoplasma pneumoniae to highlight the natural alterations of EM in a nonimmunocompromised host.