Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

Jun Takatoh; Fan Wang

doi:10.1016/j.neuron.2012.03.012

Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

Jun Takatoh
, Fan Wang

Neurobiology and Behavior

Duke University

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of . Neuron, . Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	Neuron
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2012.03.012
State	Published - Apr 12 2012

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10.1016/j.neuron.2012.03.012

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title = "Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling",

abstract = "Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of . Neuron, . Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.",

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T1 - Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

AU - Takatoh, Jun

AU - Wang, Fan

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N2 - Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of . Neuron, . Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.

AB - Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of . Neuron, . Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.

UR - https://www.scopus.com/pages/publications/84859638845

U2 - 10.1016/j.neuron.2012.03.012

DO - 10.1016/j.neuron.2012.03.012

M3 - Short survey

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AN - SCOPUS:84859638845

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JO - Neuron

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Axonally Translated SMADs Link Up BDNF and Retrograde BMP Signaling

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