Abstract
Highly sensitive: The azido analogue of methionine, azidohomoalanine (see picture), is shown to be a sensitive IR probe of protein structure, folding, and electrostatics, as demonstrated for ribosomal protein NTL9. It can be readily incorporated in to proteins, and the azido frequency is significantly blue-shifted in the thermally unfolded state.
| Original language | English |
|---|---|
| Pages (from-to) | 7473-7475 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 49 |
| Issue number | 41 |
| DOIs | |
| State | Published - Oct 4 2010 |
Keywords
- Azidohomoalanine
- Electrostatics
- Infrared spectroscopy
- Protein folding
- Protein modifications
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