Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from saccharomyces cerevisiae

Vinaya Sampath; Bingsheng Liu; Stefan Tafrov; Madhusudhan Srinivasan; Robert Rieger; Emily I. Chen; Rolf Sternglanz

doi:10.1074/jbc.M113.486274

Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from saccharomyces cerevisiae

Vinaya Sampath
, Bingsheng Liu
, Stefan Tafrov
, Madhusudhan Srinivasan
, Robert Rieger
, Emily I. Chen
, Rolf Sternglanz

Biochemistry and Cell Biology

Stony Brook University

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Based on their sequences, the closely related yeast Hpa2 and Hpa3 proteins appear to be acetyltransferases. Results: Hpa2 and Hpa3 acetylate histones, polyamines, and some small basic proteins. Conclusion: Although Hpa2 and Hpa3 are very similar in sequence, they have somewhat different substrate preferences. Significance: This is the first biochemical characterization of these two acetyltransferases.

Original language	English
Pages (from-to)	21506-21513
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.486274
State	Published - Jul 26 2013

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title = "Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from saccharomyces cerevisiae",

abstract = "Background: Based on their sequences, the closely related yeast Hpa2 and Hpa3 proteins appear to be acetyltransferases. Results: Hpa2 and Hpa3 acetylate histones, polyamines, and some small basic proteins. Conclusion: Although Hpa2 and Hpa3 are very similar in sequence, they have somewhat different substrate preferences. Significance: This is the first biochemical characterization of these two acetyltransferases.",

author = "Vinaya Sampath and Bingsheng Liu and Stefan Tafrov and Madhusudhan Srinivasan and Robert Rieger and Chen, \{Emily I.\} and Rolf Sternglanz",

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T1 - Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from saccharomyces cerevisiae

AU - Sampath, Vinaya

AU - Liu, Bingsheng

AU - Tafrov, Stefan

AU - Srinivasan, Madhusudhan

AU - Rieger, Robert

AU - Chen, Emily I.

AU - Sternglanz, Rolf

PY - 2013/7/26

Y1 - 2013/7/26

N2 - Background: Based on their sequences, the closely related yeast Hpa2 and Hpa3 proteins appear to be acetyltransferases. Results: Hpa2 and Hpa3 acetylate histones, polyamines, and some small basic proteins. Conclusion: Although Hpa2 and Hpa3 are very similar in sequence, they have somewhat different substrate preferences. Significance: This is the first biochemical characterization of these two acetyltransferases.

AB - Background: Based on their sequences, the closely related yeast Hpa2 and Hpa3 proteins appear to be acetyltransferases. Results: Hpa2 and Hpa3 acetylate histones, polyamines, and some small basic proteins. Conclusion: Although Hpa2 and Hpa3 are very similar in sequence, they have somewhat different substrate preferences. Significance: This is the first biochemical characterization of these two acetyltransferases.

UR - https://www.scopus.com/pages/publications/84881254916

U2 - 10.1074/jbc.M113.486274

DO - 10.1074/jbc.M113.486274

M3 - Article

C2 - 23775086

AN - SCOPUS:84881254916

SN - 0021-9258

VL - 288

SP - 21506

EP - 21513

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 30

ER -

Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from saccharomyces cerevisiae

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