TY - GEN
T1 - Bladder cancer diagnosis with fluorescence guided spectral domain optical coherence tomography in a rat model
AU - Wang, Z. G.
AU - Hasan, M.
AU - Liu, J. X.
AU - Pan, Y. T.
PY - 2007
Y1 - 2007
N2 - A fluorescence-image-guided spectral domain OCT (FG-SDOCT) system is described. With the recent development of spectral domain OCT, the new system is able to visualize morphological details of urinary bladder with high image fidelity (e.g., 10um/12um axial/lateral resolutions, μ110dB dynamic range) at 4-8-fold improved frame rate. Ex vivo study based on an AY-27 rat cancer model was performed to evaluate its ability to enhance the sensitivity and specificity. Total 82 specimens were examined by hyperisin-induced fluorescence imaging, OCT and histological microscopy sequentially. The preliminary results demonstrate the sensitivity and specificity of FG-SDOCT is 100% and 90% respectively, compared to 85% and 49% for fluorescence imaging. This significant improvement indicates that FG-OCT is a very promising technique for effective early bladder cancer diagnosis in combination of endoscopic OCT.
AB - A fluorescence-image-guided spectral domain OCT (FG-SDOCT) system is described. With the recent development of spectral domain OCT, the new system is able to visualize morphological details of urinary bladder with high image fidelity (e.g., 10um/12um axial/lateral resolutions, μ110dB dynamic range) at 4-8-fold improved frame rate. Ex vivo study based on an AY-27 rat cancer model was performed to evaluate its ability to enhance the sensitivity and specificity. Total 82 specimens were examined by hyperisin-induced fluorescence imaging, OCT and histological microscopy sequentially. The preliminary results demonstrate the sensitivity and specificity of FG-SDOCT is 100% and 90% respectively, compared to 85% and 49% for fluorescence imaging. This significant improvement indicates that FG-OCT is a very promising technique for effective early bladder cancer diagnosis in combination of endoscopic OCT.
UR - https://www.scopus.com/pages/publications/48749104324
U2 - 10.1109/NEBC.2007.4413284
DO - 10.1109/NEBC.2007.4413284
M3 - Conference contribution
AN - SCOPUS:48749104324
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 71
EP - 72
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -