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Blood-Brain Barrier (BBB) Permeability and Transport Measurement In Vitro and In Vivo

  • City University of New York
  • University of Southern California

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

27 Scopus citations

Abstract

Quantification of the blood-brain barrier (BBB) permeability and transport in brain tissue is crucial in understanding brain disorders and developing systemic and non-systemic drug delivery strategies to the brain. This chapter summarizes BBB permeability measurement in vitro (Part I) and the in vivo non-invasive methods for quantifying the BBB permeability to solutes and brain tissue transport in rat brain by employing intravital multiphoton microscopy and a curving fitting method by using an unsteady mass transfer mathematical model (Part II).

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages105-122
Number of pages18
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2367
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • BBB permeability
  • BBB transport
  • Cerebral microvessel
  • Effective diffusion coefficient
  • Intravital fluorescence microscopy
  • Multiphoton microscopy
  • Non-invasive
  • Rat brain
  • Unsteady mass transfer model

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