TY - JOUR
T1 - Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium
AU - Gaudet, Mia M.
AU - Olshan, Andrew F.
AU - Chuang, Shu Chun
AU - Berthiller, Julien
AU - Zhang, Zuo Feng
AU - Lissowska, Jolanta
AU - Zaridze, David
AU - Winn, Deborah M.
AU - Wei, Qingyi
AU - Talamini, Renato
AU - Szeszenia-Dabrowska, Neolilia
AU - Sturgis, Erich M.
AU - Schwartz, Stephen M.
AU - Rudnai, Peter
AU - Eluf-Neto, Jose
AU - Muscat, Joshua
AU - Morgenstern, Hal
AU - Menezes, Ana
AU - Matos, Elena
AU - Bucur, Alexandru
AU - Levi, Fabio
AU - Lazarus, Philip
AU - La Vecchia, Carlo
AU - Koifman, Sergio
AU - Kelsey, Karl
AU - Herrero, Rolando
AU - Hayes, Richard B.
AU - Franceschi, Silva
AU - Wunsch-Filho, Victor
AU - Fernandez, Leticia
AU - Fabianova, Eleonora
AU - Daudt, Alexander W.
AU - Dal Maso, Luigino
AU - Curado, Maria Paula
AU - Chen, Chu
AU - Castellsague, Xavier
AU - Benhamou, Simone
AU - Boffetta, Paolo
AU - Brennan, Paul
AU - Hashibe, Mia
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Background: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.
AB - Background: Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods: We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results: Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions: In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies.
KW - BMI
KW - Head and neck cancer
KW - Smoking
UR - https://www.scopus.com/pages/publications/77956269633
U2 - 10.1093/ije/dyp380
DO - 10.1093/ije/dyp380
M3 - Article
C2 - 20123951
AN - SCOPUS:77956269633
SN - 0300-5771
VL - 39
SP - 1091
EP - 1102
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 4
M1 - dyp380
ER -