Bone neo-formation and mineral degradation of 4Bone.® Part II: Histological and histomorphometric analysis in critical size defects in rabbits

José Luis Calvo-Guirado; Jose E. Maté-Sánchez; Rafael A. Delgado-Ruiz; Georgios E. Romanos; Piedad De Aza-Moya; Pablo Velázquez

doi:10.1111/clr.12465

Bone neo-formation and mineral degradation of 4Bone.^® Part II: Histological and histomorphometric analysis in critical size defects in rabbits

José Luis Calvo-Guirado
, Jose E. Maté-Sánchez
, Rafael A. Delgado-Ruiz
, Georgios E. Romanos
, Piedad De Aza-Moya
, Pablo Velázquez

University of Murcia
Miguel Hernández University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. Materials and method: In this study, porous HA/βTCP (4Bone^®) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic′s components HA/βTCP was 60/40 (in wt%). Results: The 4Bone^® showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52). Conclusions: 4Bone^® is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

Original language	English
Pages (from-to)	1402-1406
Number of pages	5
Journal	Clinical Oral Implants Research
Volume	26
Issue number	12
DOIs	https://doi.org/10.1111/clr.12465
State	Published - Dec 2015

Keywords

HA/βTCP
Histological analysis
Histomorphometric analysis
Resorption
Synthetic biomaterial

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10.1111/clr.12465

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@article{6abebe279c1d4cd8962a96fe89945542,

title = "Bone neo-formation and mineral degradation of 4Bone.{\textregistered} Part II: Histological and histomorphometric analysis in critical size defects in rabbits",

abstract = "To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. Materials and method: In this study, porous HA/βTCP (4Bone{\textregistered}) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic′s components HA/βTCP was 60/40 (in wt\%). Results: The 4Bone{\textregistered} showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43\% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15\% ± 3.52). Conclusions: 4Bone{\textregistered} is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95\% without loading favors new bone formation.",

keywords = "HA/βTCP, Histological analysis, Histomorphometric analysis, Resorption, Synthetic biomaterial",

author = "Calvo-Guirado, \{Jos{\'e} Luis\} and Mat{\'e}-S{\'a}nchez, \{Jose E.\} and Delgado-Ruiz, \{Rafael A.\} and Romanos, \{Georgios E.\} and \{De Aza-Moya\}, Piedad and Pablo Vel{\'a}zquez",

note = "Publisher Copyright: \& Sons Ltd.",

year = "2015",

month = dec,

doi = "10.1111/clr.12465",

language = "English",

volume = "26",

pages = "1402--1406",

journal = "Clinical Oral Implants Research",

issn = "0905-7161",

number = "12",

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Bone neo-formation and mineral degradation of 4Bone.^® Part II: Histological and histomorphometric analysis in critical size defects in rabbits. / Calvo-Guirado, José Luis; Maté-Sánchez, Jose E.; Delgado-Ruiz, Rafael A. et al.
In: Clinical Oral Implants Research, Vol. 26, No. 12, 12.2015, p. 1402-1406.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Bone neo-formation and mineral degradation of 4Bone.® Part II

T2 - Histological and histomorphometric analysis in critical size defects in rabbits

AU - Calvo-Guirado, José Luis

AU - Maté-Sánchez, Jose E.

AU - Delgado-Ruiz, Rafael A.

AU - Romanos, Georgios E.

AU - De Aza-Moya, Piedad

AU - Velázquez, Pablo

N1 - Publisher Copyright: & Sons Ltd.

PY - 2015/12

Y1 - 2015/12

N2 - To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. Materials and method: In this study, porous HA/βTCP (4Bone®) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic′s components HA/βTCP was 60/40 (in wt%). Results: The 4Bone® showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52). Conclusions: 4Bone® is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

AB - To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic. Materials and method: In this study, porous HA/βTCP (4Bone®) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic′s components HA/βTCP was 60/40 (in wt%). Results: The 4Bone® showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52). Conclusions: 4Bone® is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

KW - HA/βTCP

KW - Histological analysis

KW - Histomorphometric analysis

KW - Resorption

KW - Synthetic biomaterial

UR - https://www.scopus.com/pages/publications/84945980918

U2 - 10.1111/clr.12465

DO - 10.1111/clr.12465

M3 - Article

C2 - 25163802

AN - SCOPUS:84945980918

SN - 0905-7161

VL - 26

SP - 1402

EP - 1406

JO - Clinical Oral Implants Research

JF - Clinical Oral Implants Research

IS - 12

ER -

Bone neo-formation and mineral degradation of 4Bone.^® Part II: Histological and histomorphometric analysis in critical size defects in rabbits

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