Caged thiophosphotyrosine peptides

Keyong Zou; W. Todd Miller; Richard S. Givens; Hagan Bayley

doi:10.1002/1521-3773(20010817)40:16<3049::AID-ANIE3049>3.0.CO;2-N

Caged thiophosphotyrosine peptides

Keyong Zou
, W. Todd Miller
, Richard S. Givens
, Hagan Bayley

Physiology and Biophysics

Texas A&M University
University of Kansas

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Caged but not trapped! Caged reagents are molecules from which biological effectors are released by photolysis. Here, p-hydroxyphenacyl bromide is used to derivatize a model peptide containing a thiophosphotyrosine residue in order to mimic phosphorylation at tyrosine. Upon photolysis, a biologically active peptide is released. Peptides and proteins caged on thiophosphotyrosine will be useful in signal transduction research.

Original language	English
Pages (from-to)	3049-3051
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	16
DOIs	https://doi.org/10.1002/1521-3773(20010817)40:16<3049::AID-ANIE3049>3.0.CO;2-N
State	Published - Aug 17 2001

Keywords

Bioorganic chemistry
Peptides
Photolysis
Thiophosphate

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10.1002/1521-3773(20010817)40:16<3049::AID-ANIE3049>3.0.CO;2-N

Cite this

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abstract = "Caged but not trapped! Caged reagents are molecules from which biological effectors are released by photolysis. Here, p-hydroxyphenacyl bromide is used to derivatize a model peptide containing a thiophosphotyrosine residue in order to mimic phosphorylation at tyrosine. Upon photolysis, a biologically active peptide is released. Peptides and proteins caged on thiophosphotyrosine will be useful in signal transduction research.",

keywords = "Bioorganic chemistry, Peptides, Photolysis, Thiophosphate",

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AU - Givens, Richard S.

AU - Bayley, Hagan

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Y1 - 2001/8/17

N2 - Caged but not trapped! Caged reagents are molecules from which biological effectors are released by photolysis. Here, p-hydroxyphenacyl bromide is used to derivatize a model peptide containing a thiophosphotyrosine residue in order to mimic phosphorylation at tyrosine. Upon photolysis, a biologically active peptide is released. Peptides and proteins caged on thiophosphotyrosine will be useful in signal transduction research.

AB - Caged but not trapped! Caged reagents are molecules from which biological effectors are released by photolysis. Here, p-hydroxyphenacyl bromide is used to derivatize a model peptide containing a thiophosphotyrosine residue in order to mimic phosphorylation at tyrosine. Upon photolysis, a biologically active peptide is released. Peptides and proteins caged on thiophosphotyrosine will be useful in signal transduction research.

KW - Bioorganic chemistry

KW - Peptides

KW - Photolysis

KW - Thiophosphate

UR - https://www.scopus.com/pages/publications/0035902787

U2 - 10.1002/1521-3773(20010817)40:16<3049::AID-ANIE3049>3.0.CO;2-N

DO - 10.1002/1521-3773(20010817)40:16<3049::AID-ANIE3049>3.0.CO;2-N

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JO - Angewandte Chemie - International Edition

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IS - 16

ER -

Caged thiophosphotyrosine peptides

Abstract

Keywords

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