Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia

Anas Alrwas; Jorge R. Quesada; Luis A. Marcos; Shivang S. Mehta; Brandy L. Shattuck; Nghia D. Nguyen; Harinder S. Juneja

doi:10.1016/j.cancergen.2012.05.010

Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia

Anas Alrwas
, Jorge R. Quesada
, Luis A. Marcos
, Shivang S. Mehta
, Brandy L. Shattuck
, Nghia D. Nguyen
, Harinder S. Juneja

Infectious Diseases

University of Texas MD Anderson Cancer Center
University of Texas Health Science Center at Houston

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report an unusual case of a symptomatic patient who initially had high hemoglobin and low serum erythropoietin levels, fitting a clinical diagnosis of polycythemia vera. However, after treatment with hydroxyurea and serial phlebotomies had been started, the patient developed hypereosinophilia, fitting the category of a myeloproliferative neoplasm with eosinophilia associated with the FIP1L1-PDGFRA gene fusion, as confirmed by molecular analysis. We discuss the clinical presentation, evolution, response to treatment, and pathogenetic implications of this case.

Original language	English
Pages (from-to)	519-522
Number of pages	4
Journal	Cancer Genetics
Volume	205
Issue number	10
DOIs	https://doi.org/10.1016/j.cancergen.2012.05.010
State	Published - Oct 2012

Keywords

Chronic myeloproliferative neoplasms
Concurrent
Hypereosonophilia
Polycythemia vera

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10.1016/j.cancergen.2012.05.010

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title = "Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia",

abstract = "We report an unusual case of a symptomatic patient who initially had high hemoglobin and low serum erythropoietin levels, fitting a clinical diagnosis of polycythemia vera. However, after treatment with hydroxyurea and serial phlebotomies had been started, the patient developed hypereosinophilia, fitting the category of a myeloproliferative neoplasm with eosinophilia associated with the FIP1L1-PDGFRA gene fusion, as confirmed by molecular analysis. We discuss the clinical presentation, evolution, response to treatment, and pathogenetic implications of this case.",

keywords = "Chronic myeloproliferative neoplasms, Concurrent, Hypereosonophilia, Polycythemia vera",

author = "Anas Alrwas and Quesada, \{Jorge R.\} and Marcos, \{Luis A.\} and Mehta, \{Shivang S.\} and Shattuck, \{Brandy L.\} and Nguyen, \{Nghia D.\} and Juneja, \{Harinder S.\}",

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AU - Alrwas, Anas

AU - Quesada, Jorge R.

AU - Marcos, Luis A.

AU - Mehta, Shivang S.

AU - Shattuck, Brandy L.

AU - Nguyen, Nghia D.

AU - Juneja, Harinder S.

PY - 2012/10

Y1 - 2012/10

N2 - We report an unusual case of a symptomatic patient who initially had high hemoglobin and low serum erythropoietin levels, fitting a clinical diagnosis of polycythemia vera. However, after treatment with hydroxyurea and serial phlebotomies had been started, the patient developed hypereosinophilia, fitting the category of a myeloproliferative neoplasm with eosinophilia associated with the FIP1L1-PDGFRA gene fusion, as confirmed by molecular analysis. We discuss the clinical presentation, evolution, response to treatment, and pathogenetic implications of this case.

AB - We report an unusual case of a symptomatic patient who initially had high hemoglobin and low serum erythropoietin levels, fitting a clinical diagnosis of polycythemia vera. However, after treatment with hydroxyurea and serial phlebotomies had been started, the patient developed hypereosinophilia, fitting the category of a myeloproliferative neoplasm with eosinophilia associated with the FIP1L1-PDGFRA gene fusion, as confirmed by molecular analysis. We discuss the clinical presentation, evolution, response to treatment, and pathogenetic implications of this case.

KW - Chronic myeloproliferative neoplasms

KW - Concurrent

KW - Hypereosonophilia

KW - Polycythemia vera

UR - https://www.scopus.com/pages/publications/84867679541

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SN - 2210-7762

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JO - Cancer Genetics

JF - Cancer Genetics

IS - 10

ER -

Case of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia

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Keywords

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