Catalyst-free preparation of 1,2,4,5-tetrasubstituted imidazoles from a novel unexpected domino reaction of 2-azido acrylates and nitrones

Bao Hu; Zhao Wang; Ning Ai; Jie Zheng; Xing Hai Liu; Shang Shan; Zhongwen Wang

doi:10.1021/ol202650z

Catalyst-free preparation of 1,2,4,5-tetrasubstituted imidazoles from a novel unexpected domino reaction of 2-azido acrylates and nitrones

Bao Hu
, Zhao Wang
, Ning Ai
, Jie Zheng
, Xing Hai Liu
, Shang Shan
, Zhongwen Wang

Psychiatry

Zhejiang University of Technology
Nankai University

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base.

Original language	English
Pages (from-to)	6362-6365
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	24
DOIs	https://doi.org/10.1021/ol202650z
State	Published - Dec 16 2011

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title = "Catalyst-free preparation of 1,2,4,5-tetrasubstituted imidazoles from a novel unexpected domino reaction of 2-azido acrylates and nitrones",

abstract = "A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base.",

author = "Bao Hu and Zhao Wang and Ning Ai and Jie Zheng and Liu, \{Xing Hai\} and Shang Shan and Zhongwen Wang",

year = "2011",

month = dec,

day = "16",

doi = "10.1021/ol202650z",

language = "English",

volume = "13",

pages = "6362--6365",

journal = "Organic Letters",

issn = "1523-7060",

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T1 - Catalyst-free preparation of 1,2,4,5-tetrasubstituted imidazoles from a novel unexpected domino reaction of 2-azido acrylates and nitrones

AU - Hu, Bao

AU - Wang, Zhao

AU - Ai, Ning

AU - Zheng, Jie

AU - Liu, Xing Hai

AU - Shan, Shang

AU - Wang, Zhongwen

PY - 2011/12/16

Y1 - 2011/12/16

N2 - A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base.

AB - A highly efficient and convenient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles from readily accessible 2-azido acrylates and nitrones has been developed. This reaction proceeded under mild conditions without the assistance of any metal, acid, or base.

UR - https://www.scopus.com/pages/publications/84055224070

U2 - 10.1021/ol202650z

DO - 10.1021/ol202650z

M3 - Article

AN - SCOPUS:84055224070

SN - 1523-7060

VL - 13

SP - 6362

EP - 6365

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Catalyst-free preparation of 1,2,4,5-tetrasubstituted imidazoles from a novel unexpected domino reaction of 2-azido acrylates and nitrones

Abstract

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