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CD-Net: Histopathology Representation Learning Using Context-Detail Transformer Network

  • Stony Brook University
  • University of North Carolina at Charlotte

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

Extracting rich phenotype information, such as cell density and arrangement, from whole slide histology images (WSIs), requires analysis of large fields of view, i.e views providing more contextual information. This can be achieved through analyzing the digital slides at lower resolution. A potential drawback is missing out on details present at a higher resolution. To jointly leverage complementary information from multiple resolutions, we present a novel transformer based Context-Detail Network (CD-Net). CD-Net exploits the WSI pyramidal structure through co-training of proposed Context and Detail Modules, which operate on inputs from multiple resolutions. The residual connections between the modules enable the joint training paradigm while learning self-supervised representation for WSIs. The efficacy of CD-Net is demonstrated in classifying Lung Adenocarcinoma from Squamous cell carcinoma (N=1042 WSIs).

Original languageEnglish
Title of host publication2023 IEEE International Symposium on Biomedical Imaging, ISBI 2023
PublisherIEEE Computer Society
ISBN (Electronic)9781665473583
DOIs
StatePublished - 2023
Event20th IEEE International Symposium on Biomedical Imaging, ISBI 2023 - Cartagena, Colombia
Duration: Apr 18 2023Apr 21 2023

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2023-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference20th IEEE International Symposium on Biomedical Imaging, ISBI 2023
Country/TerritoryColombia
CityCartagena
Period04/18/2304/21/23

Keywords

  • context-detail
  • digital pathology
  • multi-resolution
  • self-supervision

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