Cell apoptosis induced by carcinogenic metals

F. Chen; V. Vallyathan; V. Castranova; X. Shi

doi:10.1023/A:1017970330982

Cell apoptosis induced by carcinogenic metals

F. Chen
, V. Vallyathan
, V. Castranova
, X. Shi

Pathology

National Institute for Occupational Safety and Health

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.

Original language	English
Pages (from-to)	183-188
Number of pages	6
Journal	Molecular and Cellular Biochemistry
Volume	222
Issue number	1-2
DOIs	https://doi.org/10.1023/A:1017970330982
State	Published - 2001

Keywords

Apoptosis
Carcinogenesis
DNA damage
Metal
ROS

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10.1023/A:1017970330982

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title = "Cell apoptosis induced by carcinogenic metals",

abstract = "Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.",

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AU - Chen, F.

AU - Vallyathan, V.

AU - Castranova, V.

AU - Shi, X.

PY - 2001

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N2 - Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.

AB - Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.

KW - Apoptosis

KW - Carcinogenesis

KW - DNA damage

KW - Metal

KW - ROS

UR - https://www.scopus.com/pages/publications/0034806639

U2 - 10.1023/A:1017970330982

DO - 10.1023/A:1017970330982

M3 - Article

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AN - SCOPUS:0034806639

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VL - 222

SP - 183

EP - 188

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

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ER -

Cell apoptosis induced by carcinogenic metals

Abstract

Keywords

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