Cell-lab on a chip: A CMOS-based microsystem for culturing and monitoring cells

Yingkai Liu; Elisabeth Smela; Nicole M. Nelson; Pamela Abshire

Cell-lab on a chip: A CMOS-based microsystem for culturing and monitoring cells

Yingkai Liu
, Elisabeth Smela
, Nicole M. Nelson
, Pamela Abshire

Electrical Engineering

University of Maryland, College Park

Research output: Contribution to journal › Conference article › peer-review

18 Scopus citations

Abstract

We describe a MEMS-on-CMOS microsystem to encage, culture, and monitor cells. The system was designed to perform long-term measurements on arrays of single electrically active cells. A MEMS process flow was developed for the fabrication of closeable micro-vials to contain each cell, a custom bio-amplifier CMOS chip was designed, fabricated, and tested, and the fabrication of the MEMS structures on this chip was demonstrated. In addition, bovine aortic smooth muscle cells were plated on the surface, and over the course of a week they adhered, formed processes, and reproduced, verifying the compatibility of the materials used with the cell culture.

Original language	English
Pages (from-to)	2534-2537
Number of pages	4
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	26 IV
State	Published - 2004
Event	Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States Duration: Sep 1 2004 → Sep 5 2004

Keywords

Cells
CMOS
Lab-on-a-chip
MEMS
Polypyrrole

Cite this

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title = "Cell-lab on a chip: A CMOS-based microsystem for culturing and monitoring cells",

abstract = "We describe a MEMS-on-CMOS microsystem to encage, culture, and monitor cells. The system was designed to perform long-term measurements on arrays of single electrically active cells. A MEMS process flow was developed for the fabrication of closeable micro-vials to contain each cell, a custom bio-amplifier CMOS chip was designed, fabricated, and tested, and the fabrication of the MEMS structures on this chip was demonstrated. In addition, bovine aortic smooth muscle cells were plated on the surface, and over the course of a week they adhered, formed processes, and reproduced, verifying the compatibility of the materials used with the cell culture.",

keywords = "Cells, CMOS, Lab-on-a-chip, MEMS, Polypyrrole",

author = "Yingkai Liu and Elisabeth Smela and Nelson, \{Nicole M.\} and Pamela Abshire",

year = "2004",

language = "English",

volume = "26 IV",

pages = "2534--2537",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

note = "Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 ; Conference date: 01-09-2004 Through 05-09-2004",

}

TY - JOUR

T1 - Cell-lab on a chip

T2 - Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004

AU - Liu, Yingkai

AU - Smela, Elisabeth

AU - Nelson, Nicole M.

AU - Abshire, Pamela

PY - 2004

Y1 - 2004

N2 - We describe a MEMS-on-CMOS microsystem to encage, culture, and monitor cells. The system was designed to perform long-term measurements on arrays of single electrically active cells. A MEMS process flow was developed for the fabrication of closeable micro-vials to contain each cell, a custom bio-amplifier CMOS chip was designed, fabricated, and tested, and the fabrication of the MEMS structures on this chip was demonstrated. In addition, bovine aortic smooth muscle cells were plated on the surface, and over the course of a week they adhered, formed processes, and reproduced, verifying the compatibility of the materials used with the cell culture.

AB - We describe a MEMS-on-CMOS microsystem to encage, culture, and monitor cells. The system was designed to perform long-term measurements on arrays of single electrically active cells. A MEMS process flow was developed for the fabrication of closeable micro-vials to contain each cell, a custom bio-amplifier CMOS chip was designed, fabricated, and tested, and the fabrication of the MEMS structures on this chip was demonstrated. In addition, bovine aortic smooth muscle cells were plated on the surface, and over the course of a week they adhered, formed processes, and reproduced, verifying the compatibility of the materials used with the cell culture.

KW - Cells

KW - CMOS

KW - Lab-on-a-chip

KW - MEMS

KW - Polypyrrole

UR - https://www.scopus.com/pages/publications/11144267918

M3 - Conference article

AN - SCOPUS:11144267918

SN - 0589-1019

VL - 26 IV

SP - 2534

EP - 2537

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Y2 - 1 September 2004 through 5 September 2004

ER -

Cell-lab on a chip: A CMOS-based microsystem for culturing and monitoring cells

Abstract

Keywords

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