Central-Nervous-System Toxoplasmosis in Homosexual and Heterosexual Adults

To the Editor: Central-nervous-system toxoplasmosis is an important and often difficult-to-diagnose cause of morbidity and mortality in patients who are immunosuppressed. In contrast, disseminated Central-nervous-system toxoplasmosis occurring in otherwise normal patients has only rarely been appreciated. Recently, however, fulminant necrotizing Central-nervous-system toxoplasmosis has been reported in previously healthy young homosexual men^{1 2 3} and in one man whose sexual preference was not given.⁴ Some of the former patients and the latter patient had Kaposi's sarcoma. No serologic data were provided, and brain histopathology was discussed in only two patients.^3,4 We have recently had occasion to examine tissue or serum specimens from three.