Ceramide: an endogenous regulator of apoptosis and growth suppresion

Marina Pushkareva; Lina M. Obeid; Yusuf A. Hannun

doi:10.1016/0167-5699(95)80184-7

Ceramide: an endogenous regulator of apoptosis and growth suppresion

Marina Pushkareva
, Lina M. Obeid
, Yusuf A. Hannun

Cancer Center

Marina Pushkareva is at The Liposome Co.
Duke University

Research output: Contribution to journal › Article › peer-review

183 Scopus citations

Abstract

The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of action of this stress-activated pathway.

Original language	English
Pages (from-to)	294-297
Number of pages	4
Journal	Immunology Today
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/0167-5699(95)80184-7
State	Published - Jun 1995

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10.1016/0167-5699(95)80184-7

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title = "Ceramide: an endogenous regulator of apoptosis and growth suppresion",

abstract = "The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of action of this stress-activated pathway.",

author = "Marina Pushkareva and Obeid, \{Lina M.\} and Hannun, \{Yusuf A.\}",

year = "1995",

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pages = "294--297",

journal = "Immunology Today",

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T1 - Ceramide

T2 - an endogenous regulator of apoptosis and growth suppresion

AU - Pushkareva, Marina

AU - Obeid, Lina M.

AU - Hannun, Yusuf A.

PY - 1995/6

Y1 - 1995/6

N2 - The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of action of this stress-activated pathway.

AB - The action of several cytokines is mediated via activation of the sphingomyelin cycle of signal transduction. Ceramide, the product of this pathway, is emerging as an intracellular messenger that mediates effects on terminal differentation, apoptosis and cell-cycle arrest. Here, Marina Pushkareva, Lina Obeid and Yusuf Hannun discuss the regulation and mechanism of action of this stress-activated pathway.

UR - https://www.scopus.com/pages/publications/0029007640

U2 - 10.1016/0167-5699(95)80184-7

DO - 10.1016/0167-5699(95)80184-7

M3 - Article

C2 - 7662099

AN - SCOPUS:0029007640

SN - 0167-5699

VL - 16

SP - 294

EP - 297

JO - Immunology Today

JF - Immunology Today

IS - 6

ER -

Ceramide: an endogenous regulator of apoptosis and growth suppresion

Abstract

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