Ceramide in the eukaryotic stress response

Yusuf A. Hannun; Chiara Luberto

doi:10.1016/S0962-8924(99)01694-3

Ceramide in the eukaryotic stress response

Research output: Contribution to journal › Review article › peer-review

676 Scopus citations

Abstract

Several extracellular agents and stress stimuli, such as tumour necrosis factor α, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.

Original language	English
Pages (from-to)	73-80
Number of pages	8
Journal	Trends in Cell Biology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/S0962-8924(99)01694-3
State	Published - 2000

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title = "Ceramide in the eukaryotic stress response",

abstract = "Several extracellular agents and stress stimuli, such as tumour necrosis factor α, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.",

author = "Hannun, \{Yusuf A.\} and Chiara Luberto",

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T1 - Ceramide in the eukaryotic stress response

AU - Hannun, Yusuf A.

AU - Luberto, Chiara

PY - 2000

Y1 - 2000

N2 - Several extracellular agents and stress stimuli, such as tumour necrosis factor α, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.

AB - Several extracellular agents and stress stimuli, such as tumour necrosis factor α, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.

UR - https://www.scopus.com/pages/publications/0033974782

U2 - 10.1016/S0962-8924(99)01694-3

DO - 10.1016/S0962-8924(99)01694-3

M3 - Review article

C2 - 10652518

AN - SCOPUS:0033974782

SN - 0962-8924

VL - 10

SP - 73

EP - 80

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 2

ER -

Ceramide in the eukaryotic stress response

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