Ceramide, stress, and a "LAG" in aging.

Lina M. Obeid; Yusuf A. Hannun

doi:10.1126/sageke.2003.39.pe27

Ceramide, stress, and a "LAG" in aging.

Lina M. Obeid
, Yusuf A. Hannun

Cancer Center

Department of Veterans Affairs

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila, and mammals, and speculate on their implications.

Original language	English
Pages (from-to)	PE27
Journal	Science of aging knowledge environment : SAGE KE
Volume	2003
Issue number	39
DOIs	https://doi.org/10.1126/sageke.2003.39.pe27
State	Published - Oct 1 2003

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10.1126/sageke.2003.39.pe27

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abstract = "Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila, and mammals, and speculate on their implications.",

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T1 - Ceramide, stress, and a "LAG" in aging.

AU - Obeid, Lina M.

AU - Hannun, Yusuf A.

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila, and mammals, and speculate on their implications.

AB - Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila, and mammals, and speculate on their implications.

UR - https://www.scopus.com/pages/publications/0142243181

U2 - 10.1126/sageke.2003.39.pe27

DO - 10.1126/sageke.2003.39.pe27

M3 - Review article

C2 - 14523222

AN - SCOPUS:0142243181

SN - 1539-6150

VL - 2003

SP - PE27

JO - Science of aging knowledge environment : SAGE KE

JF - Science of aging knowledge environment : SAGE KE

IS - 39

ER -

Ceramide, stress, and a "LAG" in aging.

Abstract

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