Challenges and opportunities in microRNA-based cancer therapeutics

Jingfang Ju

doi:10.1016/j.xcrm.2025.102057

Challenges and opportunities in microRNA-based cancer therapeutics

Jingfang Ju

Research output: Contribution to journal › Comment/debate

14 Scopus citations

Abstract

The 2024 Nobel Prize honored groundbreaking microRNA (miRNA) discoveries that unveiled the critical functions of miRNAs in fundamental biology and human health. Despite promising therapeutic potential, there are no Food and Drug Administration (FDA)-approved miRNA-based cancer therapies. This commentary discusses the progress and challenges of miRNA-based cancer therapeutics and their potential impact on future clinical oncology.

Original language	English
Article number	102057
Journal	Cell Reports Medicine
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.xcrm.2025.102057
State	Published - Apr 15 2025

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title = "Challenges and opportunities in microRNA-based cancer therapeutics",

abstract = "The 2024 Nobel Prize honored groundbreaking microRNA (miRNA) discoveries that unveiled the critical functions of miRNAs in fundamental biology and human health. Despite promising therapeutic potential, there are no Food and Drug Administration (FDA)-approved miRNA-based cancer therapies. This commentary discusses the progress and challenges of miRNA-based cancer therapeutics and their potential impact on future clinical oncology.",

author = "Jingfang Ju",

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AB - The 2024 Nobel Prize honored groundbreaking microRNA (miRNA) discoveries that unveiled the critical functions of miRNAs in fundamental biology and human health. Despite promising therapeutic potential, there are no Food and Drug Administration (FDA)-approved miRNA-based cancer therapies. This commentary discusses the progress and challenges of miRNA-based cancer therapeutics and their potential impact on future clinical oncology.

UR - https://www.scopus.com/pages/publications/105002407101

U2 - 10.1016/j.xcrm.2025.102057

DO - 10.1016/j.xcrm.2025.102057

M3 - Comment/debate

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AN - SCOPUS:105002407101

SN - 2666-3791

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JO - Cell Reports Medicine

JF - Cell Reports Medicine

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Challenges and opportunities in microRNA-based cancer therapeutics

Abstract

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