Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q

Nicholas J. Lynch; Kenneth B.M. Reid; Rocco H. Van Den Berg; Mohamed R. Daha; Leonora A.E. Leigh; Berhane Ghebrehiwet; Wallace B.L. Lim; Wilhelm J. Schwaeble

doi:10.1016/S0014-5793(97)01348-3

Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q

Nicholas J. Lynch
, Kenneth B.M. Reid
, Rocco H. Van Den Berg
, Mohamed R. Daha
, Leonora A.E. Leigh
, Berhane Ghebrehiwet
, Wallace B.L. Lim
, Wilhelm J. Schwaeble

Allergy and Immunology

University of Leicester
University of Marburg
University of Oxford
Leiden University
The University of Hong Kong

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

gGlqBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on tile cell surface. In rat serum, gC1qBP is present at ion levels.

Original language	English
Pages (from-to)	111-114
Number of pages	4
Journal	FEBS Letters
Volume	418
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(97)01348-3
State	Published - Nov 24 1997

Keywords

C1q
Complement
Receptor
gC1qBP

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10.1016/S0014-5793(97)01348-3

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title = "Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q",

abstract = "gGlqBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9\% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on tile cell surface. In rat serum, gC1qBP is present at ion levels.",

keywords = "C1q, Complement, Receptor, gC1qBP",

author = "Lynch, \{Nicholas J.\} and Reid, \{Kenneth B.M.\} and \{Van Den Berg\}, \{Rocco H.\} and Daha, \{Mohamed R.\} and Leigh, \{Leonora A.E.\} and Berhane Ghebrehiwet and Lim, \{Wallace B.L.\} and Schwaeble, \{Wilhelm J.\}",

year = "1997",

month = nov,

day = "24",

doi = "10.1016/S0014-5793(97)01348-3",

language = "English",

volume = "418",

pages = "111--114",

journal = "FEBS Letters",

issn = "0014-5793",

number = "1-2",

}

TY - JOUR

T1 - Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q

AU - Lynch, Nicholas J.

AU - Reid, Kenneth B.M.

AU - Van Den Berg, Rocco H.

AU - Daha, Mohamed R.

AU - Leigh, Leonora A.E.

AU - Ghebrehiwet, Berhane

AU - Lim, Wallace B.L.

AU - Schwaeble, Wilhelm J.

PY - 1997/11/24

Y1 - 1997/11/24

N2 - gGlqBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on tile cell surface. In rat serum, gC1qBP is present at ion levels.

AB - gGlqBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on tile cell surface. In rat serum, gC1qBP is present at ion levels.

KW - C1q

KW - Complement

KW - Receptor

KW - gC1qBP

UR - https://www.scopus.com/pages/publications/0030830353

U2 - 10.1016/S0014-5793(97)01348-3

DO - 10.1016/S0014-5793(97)01348-3

M3 - Article

C2 - 9414106

AN - SCOPUS:0030830353

SN - 0014-5793

VL - 418

SP - 111

EP - 114

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q

Abstract

Keywords

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