TY - GEN
T1 - Characterization of dynamic physiology of the bladder by optical coherence tomography
AU - Yuan, Zhijia
AU - Keng, Kerri
AU - Pan, Rubin
AU - Ren, Hugang
AU - Du, Congwu
AU - Kim, Jason
AU - Pan, Yingtian
PY - 2012
Y1 - 2012
N2 - Because of its high spatial resolution and noninvasive imaging capabilities, optical coherence tomography has been used to characterize the morphological details of various biological tissues including urinary bladder and to diagnose their alternations (e.g., cancers). In addition to static morphology, the dynamic features of tissue morphology can provide important information that can be used to diagnose the physiological and functional characteristics of biological tissues. Here, we present the imaging studies based on optical coherence tomography to characterize motion related physiology and functions of rat bladder detrusor muscles and compared the results with traditional biomechanical measurements. Our results suggest that optical coherence tomography is capable of providing quantitative evaluation of contractile functions of intact bladder (without removing bladder epithelium and connective tissue), which is potentially of more clinical relevance for future clinical diagnosis - if incorporated with cystoscopic optical coherence tomography.
AB - Because of its high spatial resolution and noninvasive imaging capabilities, optical coherence tomography has been used to characterize the morphological details of various biological tissues including urinary bladder and to diagnose their alternations (e.g., cancers). In addition to static morphology, the dynamic features of tissue morphology can provide important information that can be used to diagnose the physiological and functional characteristics of biological tissues. Here, we present the imaging studies based on optical coherence tomography to characterize motion related physiology and functions of rat bladder detrusor muscles and compared the results with traditional biomechanical measurements. Our results suggest that optical coherence tomography is capable of providing quantitative evaluation of contractile functions of intact bladder (without removing bladder epithelium and connective tissue), which is potentially of more clinical relevance for future clinical diagnosis - if incorporated with cystoscopic optical coherence tomography.
KW - Geriatric incontinence
KW - Optical coherence tomography
KW - Smooth muscle functions
KW - Tissue motion
UR - https://www.scopus.com/pages/publications/84863391315
U2 - 10.1117/12.909601
DO - 10.1117/12.909601
M3 - Conference contribution
AN - SCOPUS:84863391315
SN - 9780819488732
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Biomedical Applications of Light Scattering VI
T2 - Biomedical Applications of Light Scattering VI
Y2 - 21 January 2012 through 22 January 2012
ER -