Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells

Partha Sarathi Banerjee; Philomena Ostapchuk; Patrick Hearing; Isaac Carrico

doi:10.1021/ja104547x

Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells

Partha Sarathi Banerjee
, Philomena Ostapchuk
, Patrick Hearing
, Isaac Carrico

Stony Brook University

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.

Original language	English
Pages (from-to)	13615-13617
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	39
DOIs	https://doi.org/10.1021/ja104547x
State	Published - Oct 6 2010

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10.1021/ja104547x

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abstract = "We demonstrate here a novel two-step {"}click{"} labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.",

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AU - Banerjee, Partha Sarathi

AU - Ostapchuk, Philomena

AU - Hearing, Patrick

AU - Carrico, Isaac

PY - 2010/10/6

Y1 - 2010/10/6

N2 - We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.

AB - We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.

UR - https://www.scopus.com/pages/publications/77957293282

U2 - 10.1021/ja104547x

DO - 10.1021/ja104547x

M3 - Article

C2 - 20831164

AN - SCOPUS:77957293282

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EP - 13617

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 39

ER -

Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells

Abstract

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