TY - JOUR
T1 - Cigarette smoking and pancreatic cancer
T2 - A pooled analysis from the pancreatic cancer cohort consortium
AU - Lynch, Shannon M.
AU - Vrieling, Alina
AU - Lubin, Jay H.
AU - Kraft, Peter
AU - Mendelsohn, Julie B.
AU - Hartge, Patricia
AU - Canzian, Federico
AU - Steplowski, Emily
AU - Arslan, Alan A.
AU - Gross, Myron
AU - Helzlsouer, Kathy
AU - Jacobs, Eric J.
AU - Lacroix, Andrea
AU - Petersen, Gloria
AU - Zheng, Wei
AU - Albanes, Demetrius
AU - Amundadottir, Laufey
AU - Bingham, Sheila A.
AU - Boffetta, Paolo
AU - Boutron-Ruault, Marie Christine
AU - Chanock, Stephen J.
AU - Clipp, Sandra
AU - Hoover, Robert N.
AU - Jacobs, Kevin
AU - Johnson, Karen C.
AU - Kooperberg, Charles
AU - Luo, Juhua
AU - Messina, Catherine
AU - Palli, Domenico
AU - Patel, Alpa V.
AU - Riboli, Elio
AU - Shu, Xiao Ou
AU - Rodriguez Suarez, Laudina
AU - Thomas, Gilles
AU - Tjønneland, Anne
AU - Tobias, Geoffrey S.
AU - Tong, Elissa
AU - Trichopoulos, Dimitrios
AU - Virtamo, Jarmo
AU - Ye, Weimin
AU - Yu, Kai
AU - Zeleniuch-Jacquette, Anne
AU - Bueno-De-Mesquita, H. Bas
AU - Stolzenberg-Solomon, Rachael Z.
PY - 2009/8
Y1 - 2009/8
N2 - Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR)=1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (≥30 cigarettes/day: OR=1.75, 95% CI: 1.27, 2.42), duration (≥50 years: OR=2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (≥40 pack-years: OR=1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis.
AB - Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR)=1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (≥30 cigarettes/day: OR=1.75, 95% CI: 1.27, 2.42), duration (≥50 years: OR=2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (≥40 pack-years: OR=1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis.
KW - Pancreas
KW - Pancreatic neoplasms
KW - Smoking
KW - Tobacco use cessation
UR - https://www.scopus.com/pages/publications/68149138142
U2 - 10.1093/aje/kwp134
DO - 10.1093/aje/kwp134
M3 - Article
C2 - 19561064
AN - SCOPUS:68149138142
SN - 0002-9262
VL - 170
SP - 403
EP - 413
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 4
ER -