Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Alina Vrieling; H. Bas Bueno-de-Mesquita; Hendriek C. Boshuizen; Dominique S. Michaud; Marianne T. Severinsen; Kim Overvad; Anja Olsen; Anne Tjønneland; Françoise Clavel-Chapelon; Marie Christine Boutron-Ruault; Rudolf Kaaks; Sabine Rohrmann; Heiner Boeing; Ute Nöthlings; Antonia Trichopoulou; Eftihia Moutsiou; Vardis Dilis; Domenico Palli; Vittorio Krogh; Salvatore Panico; Rosario Tumino; Paolo Vineis; Carla H. Van Gils; Petra H.M. Peeters; Eiliv Lund; Inger T. Gram; Laudina Rodríuez; Antonio Agudo; Nerea Larrañaga; María José Sánchez; Carmen Navarro; Aurelio Barricarte; Jonas Manjer; Björn Lindkvist; Malin Sund; Weimin Ye; Sheila Bingham; Kay Tee Khaw; Andrew Roddam; Tim Key; Paolo Boffetta; Eric J. Duell; Mazda Jenab; Valentina Gallo; Elio Riboli

doi:10.1002/ijc.24907

Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Alina Vrieling
, H. Bas Bueno-de-Mesquita
, Hendriek C. Boshuizen
, Dominique S. Michaud
, Marianne T. Severinsen
, Kim Overvad
, Anja Olsen
, Anne Tjønneland
, Françoise Clavel-Chapelon
, Marie Christine Boutron-Ruault
, Rudolf Kaaks
, Sabine Rohrmann
, Heiner Boeing
, Ute Nöthlings
, Antonia Trichopoulou
, Eftihia Moutsiou
, Vardis Dilis
, Domenico Palli
, Vittorio Krogh
, Salvatore Panico

Rosario Tumino, Paolo Vineis, Carla H. Van Gils, Petra H.M. Peeters, Eiliv Lund, Inger T. Gram, Laudina Rodríuez, Antonio Agudo, Nerea Larrañaga, María José Sánchez, Carmen Navarro, Aurelio Barricarte, Jonas Manjer, Björn Lindkvist, Malin Sund, Weimin Ye, Sheila Bingham, Kay Tee Khaw, Andrew Roddam, Tim Key, Paolo Boffetta, Eric J. Duell, Mazda Jenab, Valentina Gallo, Elio Riboli

Family , Population and Preventative Medicine

National Institute of Public Health and the Environment
Utrecht University
Aarhus University
Danish Cancer Society
Institut national de la santé et de la recherche médicale
University of Paris Sud
German Cancer Research Center
German Institute of Human Nutrition Potsdam-Rehbruecke
National and Kapodistrian University of Athens
Helenic Health Foundation Athens
Centro Per Lo Studio E La Prevenzione Oncologica
IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
University of Naples Federico II
Azienda Ospedaliera Civile M.P. Arezzo
Imperial College London
Institute for Scientific Interchange Foundation
University of Tromsø – The Arctic University of Norway
Health and Health Care Services Council
Institute Catala Oncologia
Public Health Division of Gipuzkoa
CIBER Epidemiología y Salud Pública (CIBERESP)
Escuela Andaluza de Salud Publica
IMIB-Arrixaca
Instituto de Salud Publica, Pamplona
Lund University
Sahlgrenska University Hospital
Umeå University
Karolinska Institutet
University of Cambridge
University of Oxford
International Agency for Research on Cancer

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% CI = 1.36-2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% CI = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% CI = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% CI = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.

Original language	English
Pages (from-to)	2394-2403
Number of pages	10
Journal	International Journal of Cancer
Volume	126
Issue number	10
DOIs	https://doi.org/10.1002/ijc.24907
State	Published - May 15 2010

Keywords

Cigarette
Cohort study
Environmental tobacco smoke
Pancreatic cancer
Smoking

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10.1002/ijc.24907

Cite this

Vrieling, A., Bueno-de-Mesquita, H. B., Boshuizen, H. C., Michaud, D. S., Severinsen, M. T., Overvad, K., Olsen, A., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M. C., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., Moutsiou, E., Dilis, V., Palli, D., Krogh, V., ... Riboli, E. (2010). Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 126(10), 2394-2403. https://doi.org/10.1002/ijc.24907

@article{e3840ad8142e4219b87203dd44753ebe,

title = "Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95\% CI = 1.36-2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95\% CI = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95\% CI = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95\% CI = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.",

keywords = "Cigarette, Cohort study, Environmental tobacco smoke, Pancreatic cancer, Smoking",

author = "Alina Vrieling and Bueno-de-Mesquita, \{H. Bas\} and Boshuizen, \{Hendriek C.\} and Michaud, \{Dominique S.\} and Severinsen, \{Marianne T.\} and Kim Overvad and Anja Olsen and Anne Tj{\o}nneland and Fran{\c c}oise Clavel-Chapelon and Boutron-Ruault, \{Marie Christine\} and Rudolf Kaaks and Sabine Rohrmann and Heiner Boeing and Ute N{\"o}thlings and Antonia Trichopoulou and Eftihia Moutsiou and Vardis Dilis and Domenico Palli and Vittorio Krogh and Salvatore Panico and Rosario Tumino and Paolo Vineis and \{Van Gils\}, \{Carla H.\} and Peeters, \{Petra H.M.\} and Eiliv Lund and Gram, \{Inger T.\} and Laudina Rodr{\'i}uez and Antonio Agudo and Nerea Larra{\~n}aga and S{\'a}nchez, \{Mar{\'i}a Jos{\'e}\} and Carmen Navarro and Aurelio Barricarte and Jonas Manjer and Bj{\"o}rn Lindkvist and Malin Sund and Weimin Ye and Sheila Bingham and Khaw, \{Kay Tee\} and Andrew Roddam and Tim Key and Paolo Boffetta and Duell, \{Eric J.\} and Mazda Jenab and Valentina Gallo and Elio Riboli",

year = "2010",

month = may,

day = "15",

doi = "10.1002/ijc.24907",

language = "English",

volume = "126",

pages = "2394--2403",

journal = "International Journal of Cancer",

issn = "0020-7136",

number = "10",

}

Vrieling, A, Bueno-de-Mesquita, HB, Boshuizen, HC, Michaud, DS, Severinsen, MT, Overvad, K, Olsen, A, Tjønneland, A, Clavel-Chapelon, F, Boutron-Ruault, MC, Kaaks, R, Rohrmann, S, Boeing, H, Nöthlings, U, Trichopoulou, A, Moutsiou, E, Dilis, V, Palli, D, Krogh, V, Panico, S, Tumino, R, Vineis, P, Van Gils, CH, Peeters, PHM, Lund, E, Gram, IT, Rodríuez, L, Agudo, A, Larrañaga, N, Sánchez, MJ, Navarro, C, Barricarte, A, Manjer, J, Lindkvist, B, Sund, M, Ye, W, Bingham, S, Khaw, KT, Roddam, A, Key, T, Boffetta, P, Duell, EJ, Jenab, M, Gallo, V & Riboli, E 2010, 'Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 126, no. 10, pp. 2394-2403. https://doi.org/10.1002/ijc.24907

Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. / Vrieling, Alina; Bueno-de-Mesquita, H. Bas; Boshuizen, Hendriek C. et al.
In: International Journal of Cancer, Vol. 126, No. 10, 15.05.2010, p. 2394-2403.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

AU - Vrieling, Alina

AU - Bueno-de-Mesquita, H. Bas

AU - Boshuizen, Hendriek C.

AU - Michaud, Dominique S.

AU - Severinsen, Marianne T.

AU - Overvad, Kim

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Kaaks, Rudolf

AU - Rohrmann, Sabine

AU - Boeing, Heiner

AU - Nöthlings, Ute

AU - Trichopoulou, Antonia

AU - Moutsiou, Eftihia

AU - Dilis, Vardis

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Van Gils, Carla H.

AU - Peeters, Petra H.M.

AU - Lund, Eiliv

AU - Gram, Inger T.

AU - Rodríuez, Laudina

AU - Agudo, Antonio

AU - Larrañaga, Nerea

AU - Sánchez, María José

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Manjer, Jonas

AU - Lindkvist, Björn

AU - Sund, Malin

AU - Ye, Weimin

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Roddam, Andrew

AU - Key, Tim

AU - Boffetta, Paolo

AU - Duell, Eric J.

AU - Jenab, Mazda

AU - Gallo, Valentina

AU - Riboli, Elio

PY - 2010/5/15

Y1 - 2010/5/15

N2 - Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% CI = 1.36-2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% CI = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% CI = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% CI = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.

AB - Cigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% CI = 1.36-2.15), and risk increased with greater intensity and pack-years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% CI = 1.23-2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% CI = 0.96-7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% CI = 1.00-2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.

KW - Cigarette

KW - Cohort study

KW - Environmental tobacco smoke

KW - Pancreatic cancer

KW - Smoking

UR - https://www.scopus.com/pages/publications/77951213081

U2 - 10.1002/ijc.24907

DO - 10.1002/ijc.24907

M3 - Article

C2 - 19790196

AN - SCOPUS:77951213081

SN - 0020-7136

VL - 126

SP - 2394

EP - 2403

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 10

ER -

Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

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Keywords

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