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Clinical applications for immunohistochemistry of breast lesions

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Immunohistochemical analysis has been a key clinical tool that shows the protein expression of molecular markers. Expression of molecular markers in breast pathology has been used to distinguish breast cancers from benign lesions, classify subtypes of breast cancers, and determine therapeutic intervention. It is a relatively fast and efficient option in stratifying breast lesions to assist in both determining pathology diagnosis and offer strategies to the best course of clinical action. In this chapter, we discuss the use of immunohistochemistry testing for some of the key molecular markers involved in breast pathology that are crucial for classifying breast cancers and the guidelines for the interpretation of testing results that assist in clinical management.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages11-37
Number of pages27
DOIs
StatePublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
Volume1406
ISSN (Print)1064-3745

Keywords

  • Cytokeratin
  • E-cadherin
  • ER
  • HER2
  • Immunohistochemistry
  • Ki-67
  • Myoepithelial cells
  • PR

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