Coenzyme A analogues and derivatives: synthesis and applications as mechanistic probes of coenzyme a ester-utilizing enzymes

Pranab K. Mishra; Dale G. Drueckhammer

doi:10.1021/cr990010m

Coenzyme A analogues and derivatives: synthesis and applications as mechanistic probes of coenzyme a ester-utilizing enzymes

Pranab K. Mishra
, Dale G. Drueckhammer

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

A review is given on the synthesis of coenzyme A (CoA), its esters, and analogues and the application of these compounds in studies of CoA ester-utilizing enzymes. Focus is on unnatural derivatives that have been designed for specific interaction with one or a group of CoA or CoA ester-utilizing enzymes. Examples starting in the 1960s are presented.

Original language	English
Pages (from-to)	3283-3309
Number of pages	27
Journal	Chemical Reviews
Volume	100
Issue number	9
DOIs	https://doi.org/10.1021/cr990010m
State	Published - Sep 2000

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title = "Coenzyme A analogues and derivatives: synthesis and applications as mechanistic probes of coenzyme a ester-utilizing enzymes",

abstract = "A review is given on the synthesis of coenzyme A (CoA), its esters, and analogues and the application of these compounds in studies of CoA ester-utilizing enzymes. Focus is on unnatural derivatives that have been designed for specific interaction with one or a group of CoA or CoA ester-utilizing enzymes. Examples starting in the 1960s are presented.",

author = "Mishra, \{Pranab K.\} and Drueckhammer, \{Dale G.\}",

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AU - Mishra, Pranab K.

AU - Drueckhammer, Dale G.

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N2 - A review is given on the synthesis of coenzyme A (CoA), its esters, and analogues and the application of these compounds in studies of CoA ester-utilizing enzymes. Focus is on unnatural derivatives that have been designed for specific interaction with one or a group of CoA or CoA ester-utilizing enzymes. Examples starting in the 1960s are presented.

AB - A review is given on the synthesis of coenzyme A (CoA), its esters, and analogues and the application of these compounds in studies of CoA ester-utilizing enzymes. Focus is on unnatural derivatives that have been designed for specific interaction with one or a group of CoA or CoA ester-utilizing enzymes. Examples starting in the 1960s are presented.

UR - https://www.scopus.com/pages/publications/0034272404

U2 - 10.1021/cr990010m

DO - 10.1021/cr990010m

M3 - Article

AN - SCOPUS:0034272404

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SP - 3283

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JO - Chemical Reviews

JF - Chemical Reviews

IS - 9

ER -

Coenzyme A analogues and derivatives: synthesis and applications as mechanistic probes of coenzyme a ester-utilizing enzymes

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