Cognitive dysfunction lateralizes with NAA in multiple sclerosis

J. W. Pan; L. B. Krupp; L. E. Elkins; P. K. Coyle

doi:10.1207/S15324826AN0803_4

Cognitive dysfunction lateralizes with NAA in multiple sclerosis

J. W. Pan
, L. B. Krupp
, L. E. Elkins
, P. K. Coyle

Neurology

Albert Einstein College of Medicine

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Recent studies have demonstrated the utility of magnetic resonance (MR) spectroscopic imaging to evaluate axonal integrity in patients with multiple sclerosis (MS). Patient status in MS is frequently assessed by the Expanded Disability Status Scale, which emphasizes ambulation but underestimates the contribution of cognitive factors. Yet, cognitive functions of memory and processing are known to be impaired in MS. We used quantitative MR spectroscopy to determine this relation between cognitive function and N-acetyl aspartate (NAA) levels. We find a significant correlation (r = .63, p < .005) for the left periventricular (PV) NAA concentrations with performance on the verbal Selective Reminding Test. Right PV NAA was significantly (p < .02) correlated with the Tower of Hanoi performance, with r = .58.

Original language	English
Pages (from-to)	155-160
Number of pages	6
Journal	Applied Neuropsychology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1207/S15324826AN0803_4
State	Published - 2001

Keywords

Cognitive function
Lateralization
Multiple sclerosis
N-acetyl aspartate

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title = "Cognitive dysfunction lateralizes with NAA in multiple sclerosis",

abstract = "Recent studies have demonstrated the utility of magnetic resonance (MR) spectroscopic imaging to evaluate axonal integrity in patients with multiple sclerosis (MS). Patient status in MS is frequently assessed by the Expanded Disability Status Scale, which emphasizes ambulation but underestimates the contribution of cognitive factors. Yet, cognitive functions of memory and processing are known to be impaired in MS. We used quantitative MR spectroscopy to determine this relation between cognitive function and N-acetyl aspartate (NAA) levels. We find a significant correlation (r = .63, p < .005) for the left periventricular (PV) NAA concentrations with performance on the verbal Selective Reminding Test. Right PV NAA was significantly (p < .02) correlated with the Tower of Hanoi performance, with r = .58.",

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T1 - Cognitive dysfunction lateralizes with NAA in multiple sclerosis

AU - Pan, J. W.

AU - Krupp, L. B.

AU - Elkins, L. E.

AU - Coyle, P. K.

PY - 2001

Y1 - 2001

N2 - Recent studies have demonstrated the utility of magnetic resonance (MR) spectroscopic imaging to evaluate axonal integrity in patients with multiple sclerosis (MS). Patient status in MS is frequently assessed by the Expanded Disability Status Scale, which emphasizes ambulation but underestimates the contribution of cognitive factors. Yet, cognitive functions of memory and processing are known to be impaired in MS. We used quantitative MR spectroscopy to determine this relation between cognitive function and N-acetyl aspartate (NAA) levels. We find a significant correlation (r = .63, p < .005) for the left periventricular (PV) NAA concentrations with performance on the verbal Selective Reminding Test. Right PV NAA was significantly (p < .02) correlated with the Tower of Hanoi performance, with r = .58.

AB - Recent studies have demonstrated the utility of magnetic resonance (MR) spectroscopic imaging to evaluate axonal integrity in patients with multiple sclerosis (MS). Patient status in MS is frequently assessed by the Expanded Disability Status Scale, which emphasizes ambulation but underestimates the contribution of cognitive factors. Yet, cognitive functions of memory and processing are known to be impaired in MS. We used quantitative MR spectroscopy to determine this relation between cognitive function and N-acetyl aspartate (NAA) levels. We find a significant correlation (r = .63, p < .005) for the left periventricular (PV) NAA concentrations with performance on the verbal Selective Reminding Test. Right PV NAA was significantly (p < .02) correlated with the Tower of Hanoi performance, with r = .58.

KW - Cognitive function

KW - Lateralization

KW - Multiple sclerosis

KW - N-acetyl aspartate

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DO - 10.1207/S15324826AN0803_4

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VL - 8

SP - 155

EP - 160

JO - Applied Neuropsychology

JF - Applied Neuropsychology

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ER -

Cognitive dysfunction lateralizes with NAA in multiple sclerosis

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