Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances

David Warwick; José M. Arandes-Renú; Giorgio Pajardi; Jörg Witthaut; Lawrence C. Hurst

doi:10.3109/2000656X.2016.1159568

Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances

David Warwick
, José M. Arandes-Renú
, Giorgio Pajardi
, Jörg Witthaut
, Lawrence C. Hurst

Orthopaedics

University Hospital Southampton NHS Foundation Trust
University of Barcelona
IRCCS Multimedica - Milano
Schön Klinik Vogtareuth

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Objective: This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). Methods: This review is based on a literature review and practical experience. Results: This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. Conclusion: CCH has an evolving role as one of the tools available for treating Dupuytren's disease.

Original language	English
Pages (from-to)	251-261
Number of pages	11
Journal	Journal of Plastic Surgery and Hand Surgery
Volume	50
Issue number	5
DOIs	https://doi.org/10.3109/2000656X.2016.1159568
State	Published - Sep 2 2016

Keywords

clinical practice
clinical trial
Clostridium histolyticum
collagenase
dupuytren’s disease
xiaflex
xiapex

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10.3109/2000656X.2016.1159568

Cite this

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title = "Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances",

abstract = "Objective: This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). Methods: This review is based on a literature review and practical experience. Results: This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. Conclusion: CCH has an evolving role as one of the tools available for treating Dupuytren's disease.",

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doi = "10.3109/2000656X.2016.1159568",

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T2 - emerging practice patterns and treatment advances

AU - Warwick, David

AU - Arandes-Renú, José M.

AU - Pajardi, Giorgio

AU - Witthaut, Jörg

AU - Hurst, Lawrence C.

PY - 2016/9/2

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AB - Objective: This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). Methods: This review is based on a literature review and practical experience. Results: This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. Conclusion: CCH has an evolving role as one of the tools available for treating Dupuytren's disease.

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KW - xiaflex

KW - xiapex

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Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances

Abstract

Keywords

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