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Comments on the opinions published by Bergman et al. (2015) on Critical Comments on the WHO-UNEP State of the Science of Endocrine Disrupting Chemicals (Lamb et al., 2014)

  • James C. Lamb
  • , Paolo Boffetta
  • , Warren G. Foster
  • , Julie E. Goodman
  • , Karyn L. Hentz
  • , Lorenz R. Rhomberg
  • , Jane Staveley
  • , Gerard Swaen
  • , Glen Van Der Kraak
  • , Amy L. Williams
  • Exponent, Inc.
  • McMaster University
  • Gradient Corporation
  • Maastricht University
  • University of Guelph

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Recently Bergman et al. (2015) took issue with our comments (Lamb et al., 2014) on the WHO-UNEP1 report entitled the "State of the Science of Endocrine Disrupting Chemicals - 2012" (WHO 2013a). We find several key differences between their view and ours regarding the selection of studies and presentation of data related to endocrine disrupting chemicals (EDCs) under the WHO-IPCS2 definition (2002). In this response we address the factors that we think are most important: 1. the difference between hazard and risk; 2. the different approaches for hazard identification (weight of the evidence [WOE] vs. emphasizing positive findings over null results); and 3. the lack of a justification for conceptual or practical differences between EDCs and other groups of agents.

Original languageEnglish
Pages (from-to)754-757
Number of pages4
JournalRegulatory Toxicology and Pharmacology
Volume73
Issue number3
DOIs
StatePublished - Dec 1 2015

Keywords

  • Endocrine disrupting chemicals (EDC)
  • Endocrine mode-of-action
  • Hazard assessment
  • Risk characterization
  • Weight of evidence

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