Continuous-Flow Syntheses of Active Pharmaceutical Ingredients

R. L. Beingessner; A. R. Longstreet; T. A. McTeague; L. P. Kelly; H. Seo; T. H. Tran; A. C. Wicker; T. F. Jamison

doi:10.1055/sos-SD-228-00239

Continuous-Flow Syntheses of Active Pharmaceutical Ingredients

R. L. Beingessner
, A. R. Longstreet
, T. A. McTeague
, L. P. Kelly
, H. Seo
, T. H. Tran
, A. C. Wicker
, T. F. Jamison

Materials Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter describes synthetic strategies and technologies used to perform multistep flow syntheses of active pharmaceutical ingredients (APIs). The APIs or potential drug candidates highlighted are efavirenz, imatinib, (-)-oseltamivir, ibuprofen, rolipram, methylphenidate hydrochloride, and rufinamide.

Original language	English
Title of host publication	Science of Synthesis
Editors	T.F. Jamison, G. Koch
Publisher	Georg Thieme Verlag
Pages	429-462
Number of pages	34
Edition	5
ISBN (Electronic)	9783132423350
ISBN (Print)	9783132423312
DOIs	https://doi.org/10.1055/sos-SD-228-00239
State	Published - 2018

Publication series

Name	Science of Synthesis
Number	5
Volume	2018
ISSN (Print)	2510-5469
ISSN (Electronic)	2566-7297

Keywords

biphasic synthesis
continuous-flow synthesis
copper tubing reactors
essential medicines
fully continuous
inline purification
inline separation
multistep processes
packed-bed reactors
polymer-supported catalysts
semi-continuous

Access to Document

10.1055/sos-SD-228-00239

Cite this

Beingessner, R. L., Longstreet, A. R., McTeague, T. A., Kelly, L. P., Seo, H., Tran, T. H., Wicker, A. C., & Jamison, T. F. (2018). Continuous-Flow Syntheses of Active Pharmaceutical Ingredients. In T. F. Jamison, & G. Koch (Eds.), Science of Synthesis (5 ed., pp. 429-462). (Science of Synthesis; Vol. 2018, No. 5). Georg Thieme Verlag. https://doi.org/10.1055/sos-SD-228-00239

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doi = "10.1055/sos-SD-228-00239",

language = "English",

isbn = "9783132423312",

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AU - Tran, T. H.

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KW - inline separation

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ER -

Continuous-Flow Syntheses of Active Pharmaceutical Ingredients

Abstract

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Keywords

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