Death of an enzyme: suicide repair of DNA

Bruce Demple; Peter Karran

doi:10.1016/0968-0004(83)90238-4

Death of an enzyme: suicide repair of DNA

Bruce Demple
, Peter Karran

Pharmacological Sciences

Cancer Research UK

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Alkylation of DNA forms lethal and mutagenic lesions, most of which are repaired by conventional enzymes. A unique activity has been discovered which corrects an important mutagenic adduct in one step, by a self-destructive mechanism.

Original language	English
Pages (from-to)	137-139
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0968-0004(83)90238-4
State	Published - Apr 1983

Access to Document

10.1016/0968-0004(83)90238-4

Cite this

@article{8f4bdb7f095f45f3a892d68bf05a7dd1,

title = "Death of an enzyme: suicide repair of DNA",

abstract = "Alkylation of DNA forms lethal and mutagenic lesions, most of which are repaired by conventional enzymes. A unique activity has been discovered which corrects an important mutagenic adduct in one step, by a self-destructive mechanism.",

author = "Bruce Demple and Peter Karran",

year = "1983",

month = apr,

doi = "10.1016/0968-0004(83)90238-4",

language = "English",

volume = "8",

pages = "137--139",

journal = "Trends in Biochemical Sciences",

issn = "0968-0004",

number = "4",

}

TY - JOUR

T1 - Death of an enzyme

T2 - suicide repair of DNA

AU - Demple, Bruce

AU - Karran, Peter

PY - 1983/4

Y1 - 1983/4

N2 - Alkylation of DNA forms lethal and mutagenic lesions, most of which are repaired by conventional enzymes. A unique activity has been discovered which corrects an important mutagenic adduct in one step, by a self-destructive mechanism.

AB - Alkylation of DNA forms lethal and mutagenic lesions, most of which are repaired by conventional enzymes. A unique activity has been discovered which corrects an important mutagenic adduct in one step, by a self-destructive mechanism.

UR - https://www.scopus.com/pages/publications/0000536659

U2 - 10.1016/0968-0004(83)90238-4

DO - 10.1016/0968-0004(83)90238-4

M3 - Article

AN - SCOPUS:0000536659

SN - 0968-0004

VL - 8

SP - 137

EP - 139

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 4

ER -

Death of an enzyme: suicide repair of DNA

Abstract

Access to Document

Other files and links

Fingerprint

Cite this