TY - GEN
T1 - Deformation heterogeneity radiomics to predict molecular subtypes of pediatric Medulloblastoma on routine MRI
AU - Iyer, Sukanya
AU - Ismail, Marwa
AU - Tamrazi, Benita
AU - Margol, Ashley
AU - Verma, Ruchika
AU - Correa, Ramon
AU - Prasanna, Prateek
AU - Beig, Niha
AU - Bera, Kaustav
AU - Statsevych, Volodymyr
AU - Judkins, Alexander
AU - Madabhushi, Anant
AU - Tiwari, Pallavi
N1 - Publisher Copyright:
© 2019 SPIE.
PY - 2019
Y1 - 2019
N2 - Medulloblastoma (MB) is the most common malignant brain tumor in children. Currently, »one-size-fits-all» radiation and chemotherapy treatment regimen is employed for treating MB patient, causing at least some children to undergo highly aggressive and in some cases, inadequate radiation therapy. Consequently, there is a need for prognostic and predictive tools for identifying disease aggressiveness and ultimately which patients with MB may be able to benefit from de-escalation of therapy. Genomic characterization of MB has recently identified 4 distinct molecular subgroups: Sonic Hedgehog (SHH), Wingless (WNT), Group 3, Group 4 each exhibiting different clinical behavior. The molecular sub-types have unique risk-profiles and outcomes, and patients could potentially benefit from sub-group specific treatments. However, the transition of these molecular MB subtypes into clinical practice has been limited due to challenges in availability of molecular profiling in most hospitals, as well as variability in clinical assessment. In this work, we present a radiomic feature that captures subtle tissue deformations caused due to the impact of tumor growth on the normal-appearing brain around tumor (BAT), to distinguish molecular sub-types of MB. First, we obtain voxel-wise deformation magnitude from the deformation orientations, after registering Gadolinium (Gd)-enhanced T1-w MRI scan for every study to a normal age-specific T1w MRI template. Deformation statistics are then computed within every 5mm annular BAT region, 0 < d < 60mm, where d is the distance from the tumor infiltrating edge, to capture subtle localized deformation changes around the tumor. Our results using multi-class comparison via one-way ANOVA and post-hoc comparison showed significant differences across deformation magnitudes obtained for Group 3, Group 4, and SHH molecular sub-types, observed up to 15-mm outside the infiltrating edge. Our feasibility results suggest that the subtle deformation features in BAT observed on routine Gd-T1w MRI may potentially serve as surrogate markers to non-invasively characterize molecular sub-types of pediatric MB.
AB - Medulloblastoma (MB) is the most common malignant brain tumor in children. Currently, »one-size-fits-all» radiation and chemotherapy treatment regimen is employed for treating MB patient, causing at least some children to undergo highly aggressive and in some cases, inadequate radiation therapy. Consequently, there is a need for prognostic and predictive tools for identifying disease aggressiveness and ultimately which patients with MB may be able to benefit from de-escalation of therapy. Genomic characterization of MB has recently identified 4 distinct molecular subgroups: Sonic Hedgehog (SHH), Wingless (WNT), Group 3, Group 4 each exhibiting different clinical behavior. The molecular sub-types have unique risk-profiles and outcomes, and patients could potentially benefit from sub-group specific treatments. However, the transition of these molecular MB subtypes into clinical practice has been limited due to challenges in availability of molecular profiling in most hospitals, as well as variability in clinical assessment. In this work, we present a radiomic feature that captures subtle tissue deformations caused due to the impact of tumor growth on the normal-appearing brain around tumor (BAT), to distinguish molecular sub-types of MB. First, we obtain voxel-wise deformation magnitude from the deformation orientations, after registering Gadolinium (Gd)-enhanced T1-w MRI scan for every study to a normal age-specific T1w MRI template. Deformation statistics are then computed within every 5mm annular BAT region, 0 < d < 60mm, where d is the distance from the tumor infiltrating edge, to capture subtle localized deformation changes around the tumor. Our results using multi-class comparison via one-way ANOVA and post-hoc comparison showed significant differences across deformation magnitudes obtained for Group 3, Group 4, and SHH molecular sub-types, observed up to 15-mm outside the infiltrating edge. Our feasibility results suggest that the subtle deformation features in BAT observed on routine Gd-T1w MRI may potentially serve as surrogate markers to non-invasively characterize molecular sub-types of pediatric MB.
KW - Deformation Features
KW - Medulloblastoma
KW - MRI
KW - Personalized medic ine
KW - Radiogenomics
KW - Radiomics
UR - https://www.scopus.com/pages/publications/85068134180
U2 - 10.1117/12.2513567
DO - 10.1117/12.2513567
M3 - Conference contribution
AN - SCOPUS:85068134180
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2019
A2 - Mori, Kensaku
A2 - Hahn, Horst K.
PB - SPIE
T2 - Medical Imaging 2019: Computer-Aided Diagnosis
Y2 - 17 February 2019 through 20 February 2019
ER -