Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions

Songnian Lin; Kan Fang; Masaru Hashimoto; Koji Nakanishi; Iwao Ojima

doi:10.1016/S0040-4039(00)00627-4

Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions

Songnian Lin
, Kan Fang
, Masaru Hashimoto
, Koji Nakanishi
, Iwao Ojima

Chemistry

Stony Brook University
Columbia University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel-microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyl- diazirinyl-phenoxyacetyl group at C-3'N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	4287-4290
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	22
DOIs	https://doi.org/10.1016/S0040-4039(00)00627-4
State	Published - Jun 8 2000

Keywords

Bifunctional probe
Biotin
Diazirine
Photoaffinity label
Taxoid

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10.1016/S0040-4039(00)00627-4

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title = "Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions",

abstract = "A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel-microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyl- diazirinyl-phenoxyacetyl group at C-3'N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography. (C) 2000 Elsevier Science Ltd.",

keywords = "Bifunctional probe, Biotin, Diazirine, Photoaffinity label, Taxoid",

author = "Songnian Lin and Kan Fang and Masaru Hashimoto and Koji Nakanishi and Iwao Ojima",

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T1 - Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions

AU - Lin, Songnian

AU - Fang, Kan

AU - Hashimoto, Masaru

AU - Nakanishi, Koji

AU - Ojima, Iwao

PY - 2000/6/8

Y1 - 2000/6/8

N2 - A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel-microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyl- diazirinyl-phenoxyacetyl group at C-3'N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography. (C) 2000 Elsevier Science Ltd.

AB - A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel-microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyl- diazirinyl-phenoxyacetyl group at C-3'N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography. (C) 2000 Elsevier Science Ltd.

KW - Bifunctional probe

KW - Biotin

KW - Diazirine

KW - Photoaffinity label

KW - Taxoid

UR - https://www.scopus.com/pages/publications/0034622036

U2 - 10.1016/S0040-4039(00)00627-4

DO - 10.1016/S0040-4039(00)00627-4

M3 - Article

AN - SCOPUS:0034622036

SN - 0040-4039

VL - 41

SP - 4287

EP - 4290

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel-microtubules interactions

Abstract

Keywords

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