Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents

Yoshio Hayashi; Yoshimi Sato; Jun Katada; Yoshimi Takiguchi; Iwao Ojima; Isao Uno

doi:10.1016/0960-894X(96)00224-7

Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents

Yoshio Hayashi
, Yoshimi Sato
, Jun Katada
, Yoshimi Takiguchi
, Iwao Ojima
, Isao Uno

Chemistry

Nippon Steel Corporation

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The structure-activity relationships of N-terminal modified RGD peptides against platelet aggregation inhibitory activity were studied, and Orotyl- Ser-Arg-Gly-Asp-Trp (NSL-9403) was found to be a new and effective anti- thrombotic agent during extracorporeal circulation.

Original language	English
Pages (from-to)	1351-1356
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/0960-894X(96)00224-7
State	Published - Jun 18 1996

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10.1016/0960-894X(96)00224-7

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title = "Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents",

abstract = "The structure-activity relationships of N-terminal modified RGD peptides against platelet aggregation inhibitory activity were studied, and Orotyl- Ser-Arg-Gly-Asp-Trp (NSL-9403) was found to be a new and effective anti- thrombotic agent during extracorporeal circulation.",

author = "Yoshio Hayashi and Yoshimi Sato and Jun Katada and Yoshimi Takiguchi and Iwao Ojima and Isao Uno",

year = "1996",

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T1 - Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents

AU - Hayashi, Yoshio

AU - Sato, Yoshimi

AU - Katada, Jun

AU - Takiguchi, Yoshimi

AU - Ojima, Iwao

AU - Uno, Isao

PY - 1996/6/18

Y1 - 1996/6/18

N2 - The structure-activity relationships of N-terminal modified RGD peptides against platelet aggregation inhibitory activity were studied, and Orotyl- Ser-Arg-Gly-Asp-Trp (NSL-9403) was found to be a new and effective anti- thrombotic agent during extracorporeal circulation.

AB - The structure-activity relationships of N-terminal modified RGD peptides against platelet aggregation inhibitory activity were studied, and Orotyl- Ser-Arg-Gly-Asp-Trp (NSL-9403) was found to be a new and effective anti- thrombotic agent during extracorporeal circulation.

UR - https://www.scopus.com/pages/publications/0029941208

U2 - 10.1016/0960-894X(96)00224-7

DO - 10.1016/0960-894X(96)00224-7

M3 - Article

AN - SCOPUS:0029941208

SN - 0960-894X

VL - 6

SP - 1351

EP - 1356

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Design and synthesis of new antagonist peptides for platelet GPIIb/IIIa receptor as anti-thrombotic agents

Abstract

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