Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids

Iwao Ojima; Xudong Geng; Songnian Lin; Paula Pera; Ralph J. Bernacki

doi:10.1016/S0960-894X(01)00747-8

Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids

Iwao Ojima
, Xudong Geng
, Songnian Lin
, Paula Pera
, Ralph J. Bernacki

Chemistry

Stony Brook University
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3′ N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09-0.3 μM IC₅₀ values.

Original language	English
Pages (from-to)	349-352
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(01)00747-8
State	Published - Feb 11 2002

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abstract = "A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3′ N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09-0.3 μM IC50 values.",

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AU - Ojima, Iwao

AU - Geng, Xudong

AU - Lin, Songnian

AU - Pera, Paula

AU - Bernacki, Ralph J.

PY - 2002/2/11

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AB - A series of novel macrocyclic taxoids was designed and synthesized by connecting the C-2 and C-3′ N positions of the taxoid framework with various tethers. Cytotoxicity of these macrocyclic taxoids was evaluated against a human breast cancer cell line LCC6-WT, and a couple of the taxoids exhibited 0.09-0.3 μM IC50 values.

UR - https://www.scopus.com/pages/publications/0037059894

U2 - 10.1016/S0960-894X(01)00747-8

DO - 10.1016/S0960-894X(01)00747-8

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Design, synthesis and biological activity of novel C2-C3′ N-Linked macrocyclic taxoids

Abstract

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