Detection of Borrelia burgdorferi antigens in cerebrospinal fluid

P. K. Coyle; Z. Deng; S. E. Schutzer; A. L. Belman; J. Benach; L. B. Krupp; B. Luft

Detection of Borrelia burgdorferi antigens in cerebrospinal fluid

P. K. Coyle
, Z. Deng
, S. E. Schutzer
, A. L. Belman
, J. Benach
, L. B. Krupp
, B. Luft

Stony Brook University
Rutgers - The State University of New Jersey, New Brunswick

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.

Original language	English
Pages (from-to)	1093-1097
Number of pages	5
Journal	Neurology
Volume	43
Issue number	6
State	Published - Jun 1993

Cite this

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title = "Detection of Borrelia burgdorferi antigens in cerebrospinal fluid",

abstract = "We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49\%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3\%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55\%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.",

author = "Coyle, \{P. K.\} and Z. Deng and Schutzer, \{S. E.\} and Belman, \{A. L.\} and J. Benach and Krupp, \{L. B.\} and B. Luft",

year = "1993",

month = jun,

language = "English",

volume = "43",

pages = "1093--1097",

journal = "Neurology",

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T1 - Detection of Borrelia burgdorferi antigens in cerebrospinal fluid

AU - Coyle, P. K.

AU - Deng, Z.

AU - Schutzer, S. E.

AU - Belman, A. L.

AU - Benach, J.

AU - Krupp, L. B.

AU - Luft, B.

PY - 1993/6

Y1 - 1993/6

N2 - We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.

AB - We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.

UR - https://www.scopus.com/pages/publications/0027175577

M3 - Article

C2 - 8170548

AN - SCOPUS:0027175577

SN - 0028-3878

VL - 43

SP - 1093

EP - 1097

JO - Neurology

JF - Neurology

IS - 6

ER -

Detection of Borrelia burgdorferi antigens in cerebrospinal fluid

Abstract

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