Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

Ludovica Leomanni; Giulia Collatuzzo; Emanuele Sansone; Emma Sala; Giuseppe De Palma; Stefano Porru; Gianluca Spiteri; Maria Grazia Lourdes Monaco; Daniela Basso; Sofia Pavanello; Maria Luisa Scapellato; Francesca Larese Filon; Luca Cegolon; Marcella Mauro; Vittorio Lodi; Tiziana Lazzarotto; Ivan Noreña; Christina Reinkemeyer; Le Thi Thu Giang; Eleonóra Fabiánová; Jozef Strhársky; Marco Dell’Omo; Nicola Murgia; Lucía A. Carrasco-Ribelles; Concepción Violán; Dana Mates; Agripina Rascu; Luigi Vimercati; Luigi De Maria; Shuffield S. Asafo; Giorgia Ditano; Mahsa Abedini; Paolo Boffetta

doi:10.3390/vaccines11101527

Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

Ludovica Leomanni
, Giulia Collatuzzo
, Emanuele Sansone
, Emma Sala
, Giuseppe De Palma
, Stefano Porru
, Gianluca Spiteri
, Maria Grazia Lourdes Monaco
, Daniela Basso
, Sofia Pavanello
, Maria Luisa Scapellato
, Francesca Larese Filon
, Luca Cegolon
, Marcella Mauro
, Vittorio Lodi
, Tiziana Lazzarotto
, Ivan Noreña
, Christina Reinkemeyer
, Le Thi Thu Giang
, Eleonóra Fabiánová

Jozef Strhársky, Marco Dell’Omo, Nicola Murgia, Lucía A. Carrasco-Ribelles, Concepción Violán, Dana Mates, Agripina Rascu, Luigi Vimercati, Luigi De Maria, Shuffield S. Asafo, Giorgia Ditano, Mahsa Abedini, Paolo Boffetta

Family , Population and Preventative Medicine

University of Bologna
University of Brescia
University of Verona
Hospital Trust of Verona
University of Padua
Azienda Ospedaliera di Padova
University of Trieste
IRCCS University Hospital
Ludwig Maximilian University of Munich
Regional Authority of Public Health
University of Perugia
University of Ferrara
Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol)
Direcció d’Atenció Primària Metropolitana Nord Institut Català de Salut
Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAPJGol)
Instituto de Salud Carlos III
Germans Trias i Pujol Research Institute (IGTP)
Autonomous University of Barcelona
National Institute of Public Health
Medicine and Pharmacy “Carol Davila”
University of Bari

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed the determinants of 12-month serology in a multicenter European cohort of vaccinated healthcare workers (HCW). Methods: We analyzed the sociodemographic characteristics and levels of anti-SARS-CoV-2 spike antibodies (IgG) in a cohort of 16,101 vaccinated HCW from eleven centers in Germany, Italy, Romania, Slovakia and Spain. Considering the skewness of the distribution, the serological levels were transformed using log or cubic standardization and normalized by dividing them by center-specific standard errors. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of one standard deviation of log or cubic antibody level and the corresponding 95% confidence interval (CI) for different factors and combined them in random-effects meta-analyses. Results: We included 16,101 HCW in the analysis. A high antibody level was positively associated with age (RR = 1.04, 95% CI = 1.00–1.08 per 10-year increase), previous infection (RR = 1.78, 95% CI 1.29–2.45) and use of Spikevax [Moderna] with combinations compared to Comirnaty [BioNTech/Pfizer] (RR = 1.07, 95% CI 0.97–1.19) and was negatively associated with the time since last vaccine (RR = 0.94, 95% CI 0.91–0.98 per 30-day increase). Conclusions: These results provide insight about vaccine-induced immunity to SARS-CoV-2, an analysis of its determinants and quantification of the antibody decay trend with time since vaccination.

Original language	English
Article number	1527
Journal	Vaccines
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/vaccines11101527
State	Published - Oct 2023

Keywords

antibody level
coronavirus
COVID-19
immunization
occupational health
serology
vaccine

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10.3390/vaccines11101527

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Leomanni, L., Collatuzzo, G., Sansone, E., Sala, E., De Palma, G., Porru, S., Spiteri, G., Monaco, M. G. L., Basso, D., Pavanello, S., Scapellato, M. L., Larese Filon, F., Cegolon, L., Mauro, M., Lodi, V., Lazzarotto, T., Noreña, I., Reinkemeyer, C., Giang, L. T. T., ... Boffetta, P. (2023). Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project. Vaccines, 11(10), Article 1527. https://doi.org/10.3390/vaccines11101527

@article{ebc0db84681148128ce86b4f879f1e88,

title = "Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project",

abstract = "Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed the determinants of 12-month serology in a multicenter European cohort of vaccinated healthcare workers (HCW). Methods: We analyzed the sociodemographic characteristics and levels of anti-SARS-CoV-2 spike antibodies (IgG) in a cohort of 16,101 vaccinated HCW from eleven centers in Germany, Italy, Romania, Slovakia and Spain. Considering the skewness of the distribution, the serological levels were transformed using log or cubic standardization and normalized by dividing them by center-specific standard errors. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of one standard deviation of log or cubic antibody level and the corresponding 95\% confidence interval (CI) for different factors and combined them in random-effects meta-analyses. Results: We included 16,101 HCW in the analysis. A high antibody level was positively associated with age (RR = 1.04, 95\% CI = 1.00–1.08 per 10-year increase), previous infection (RR = 1.78, 95\% CI 1.29–2.45) and use of Spikevax [Moderna] with combinations compared to Comirnaty [BioNTech/Pfizer] (RR = 1.07, 95\% CI 0.97–1.19) and was negatively associated with the time since last vaccine (RR = 0.94, 95\% CI 0.91–0.98 per 30-day increase). Conclusions: These results provide insight about vaccine-induced immunity to SARS-CoV-2, an analysis of its determinants and quantification of the antibody decay trend with time since vaccination.",

keywords = "antibody level, coronavirus, COVID-19, immunization, occupational health, serology, vaccine",

author = "Ludovica Leomanni and Giulia Collatuzzo and Emanuele Sansone and Emma Sala and \{De Palma\}, Giuseppe and Stefano Porru and Gianluca Spiteri and Monaco, \{Maria Grazia Lourdes\} and Daniela Basso and Sofia Pavanello and Scapellato, \{Maria Luisa\} and \{Larese Filon\}, Francesca and Luca Cegolon and Marcella Mauro and Vittorio Lodi and Tiziana Lazzarotto and Ivan Nore{\~n}a and Christina Reinkemeyer and Giang, \{Le Thi Thu\} and Eleon{\'o}ra Fabi{\'a}nov{\'a} and Jozef Strh{\'a}rsky and Marco Dell{\textquoteright}Omo and Nicola Murgia and Carrasco-Ribelles, \{Luc{\'i}a A.\} and Concepci{\'o}n Viol{\'a}n and Dana Mates and Agripina Rascu and Luigi Vimercati and \{De Maria\}, Luigi and Asafo, \{Shuffield S.\} and Giorgia Ditano and Mahsa Abedini and Paolo Boffetta",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = oct,

doi = "10.3390/vaccines11101527",

language = "English",

volume = "11",

journal = "Vaccines",

issn = "2076-393X",

number = "10",

}

Leomanni, L, Collatuzzo, G, Sansone, E, Sala, E, De Palma, G, Porru, S, Spiteri, G, Monaco, MGL, Basso, D, Pavanello, S, Scapellato, ML, Larese Filon, F, Cegolon, L, Mauro, M, Lodi, V, Lazzarotto, T, Noreña, I, Reinkemeyer, C, Giang, LTT, Fabiánová, E, Strhársky, J, Dell’Omo, M, Murgia, N, Carrasco-Ribelles, LA, Violán, C, Mates, D, Rascu, A, Vimercati, L, De Maria, L, Asafo, SS, Ditano, G, Abedini, M & Boffetta, P 2023, 'Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project', Vaccines, vol. 11, no. 10, 1527. https://doi.org/10.3390/vaccines11101527

TY - JOUR

T1 - Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

AU - Leomanni, Ludovica

AU - Collatuzzo, Giulia

AU - Sansone, Emanuele

AU - Sala, Emma

AU - De Palma, Giuseppe

AU - Porru, Stefano

AU - Spiteri, Gianluca

AU - Monaco, Maria Grazia Lourdes

AU - Basso, Daniela

AU - Pavanello, Sofia

AU - Scapellato, Maria Luisa

AU - Larese Filon, Francesca

AU - Cegolon, Luca

AU - Mauro, Marcella

AU - Lodi, Vittorio

AU - Lazzarotto, Tiziana

AU - Noreña, Ivan

AU - Reinkemeyer, Christina

AU - Giang, Le Thi Thu

AU - Fabiánová, Eleonóra

AU - Strhársky, Jozef

AU - Dell’Omo, Marco

AU - Murgia, Nicola

AU - Carrasco-Ribelles, Lucía A.

AU - Violán, Concepción

AU - Mates, Dana

AU - Rascu, Agripina

AU - Vimercati, Luigi

AU - De Maria, Luigi

AU - Asafo, Shuffield S.

AU - Ditano, Giorgia

AU - Abedini, Mahsa

AU - Boffetta, Paolo

PY - 2023/10

Y1 - 2023/10

N2 - Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed the determinants of 12-month serology in a multicenter European cohort of vaccinated healthcare workers (HCW). Methods: We analyzed the sociodemographic characteristics and levels of anti-SARS-CoV-2 spike antibodies (IgG) in a cohort of 16,101 vaccinated HCW from eleven centers in Germany, Italy, Romania, Slovakia and Spain. Considering the skewness of the distribution, the serological levels were transformed using log or cubic standardization and normalized by dividing them by center-specific standard errors. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of one standard deviation of log or cubic antibody level and the corresponding 95% confidence interval (CI) for different factors and combined them in random-effects meta-analyses. Results: We included 16,101 HCW in the analysis. A high antibody level was positively associated with age (RR = 1.04, 95% CI = 1.00–1.08 per 10-year increase), previous infection (RR = 1.78, 95% CI 1.29–2.45) and use of Spikevax [Moderna] with combinations compared to Comirnaty [BioNTech/Pfizer] (RR = 1.07, 95% CI 0.97–1.19) and was negatively associated with the time since last vaccine (RR = 0.94, 95% CI 0.91–0.98 per 30-day increase). Conclusions: These results provide insight about vaccine-induced immunity to SARS-CoV-2, an analysis of its determinants and quantification of the antibody decay trend with time since vaccination.

AB - Background: The effectiveness of the immunity provided by SARS-CoV-2 vaccines is an important public health issue. We analyzed the determinants of 12-month serology in a multicenter European cohort of vaccinated healthcare workers (HCW). Methods: We analyzed the sociodemographic characteristics and levels of anti-SARS-CoV-2 spike antibodies (IgG) in a cohort of 16,101 vaccinated HCW from eleven centers in Germany, Italy, Romania, Slovakia and Spain. Considering the skewness of the distribution, the serological levels were transformed using log or cubic standardization and normalized by dividing them by center-specific standard errors. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of one standard deviation of log or cubic antibody level and the corresponding 95% confidence interval (CI) for different factors and combined them in random-effects meta-analyses. Results: We included 16,101 HCW in the analysis. A high antibody level was positively associated with age (RR = 1.04, 95% CI = 1.00–1.08 per 10-year increase), previous infection (RR = 1.78, 95% CI 1.29–2.45) and use of Spikevax [Moderna] with combinations compared to Comirnaty [BioNTech/Pfizer] (RR = 1.07, 95% CI 0.97–1.19) and was negatively associated with the time since last vaccine (RR = 0.94, 95% CI 0.91–0.98 per 30-day increase). Conclusions: These results provide insight about vaccine-induced immunity to SARS-CoV-2, an analysis of its determinants and quantification of the antibody decay trend with time since vaccination.

KW - antibody level

KW - coronavirus

KW - COVID-19

KW - immunization

KW - occupational health

KW - serology

KW - vaccine

UR - https://www.scopus.com/pages/publications/85175264056

U2 - 10.3390/vaccines11101527

DO - 10.3390/vaccines11101527

M3 - Article

AN - SCOPUS:85175264056

SN - 2076-393X

VL - 11

JO - Vaccines

JF - Vaccines

IS - 10

M1 - 1527

ER -

Determinants of Anti-S Immune Response at 12 Months after SARS-CoV-2 Vaccination in a Multicentric European Cohort of Healthcare Workers—ORCHESTRA Project

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