Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique

Takeo Harada; Jun Katada; Akira Tachiki; Tohru Asari; Kiyoko Iijima; Isao Uno; Iwao Ojima; Yoshio Hayashi

doi:10.1016/S0960-894X(96)00610-5

Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique

Takeo Harada
, Jun Katada
, Akira Tachiki
, Tohru Asari
, Kiyoko Iijima
, Isao Uno
, Iwao Ojima
, Yoshio Hayashi

Chemistry

Nippon Steel Corporation

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC₅₀ value of collagen induced platelet aggregation inhibitory activity is 92 nM.

Original language	English
Pages (from-to)	209-212
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(96)00610-5
State	Published - Jan 21 1997

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title = "Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique",

abstract = "The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.",

author = "Takeo Harada and Jun Katada and Akira Tachiki and Tohru Asari and Kiyoko Iijima and Isao Uno and Iwao Ojima and Yoshio Hayashi",

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AU - Harada, Takeo

AU - Katada, Jun

AU - Tachiki, Akira

AU - Asari, Tohru

AU - Iijima, Kiyoko

AU - Uno, Isao

AU - Ojima, Iwao

AU - Hayashi, Yoshio

PY - 1997/1/21

Y1 - 1997/1/21

N2 - The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.

AB - The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-95301, is presented. The combinatorial technique was engaged in the lead compound discovery process and optimization process to find (+)-NSL-95301. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM.

UR - https://www.scopus.com/pages/publications/0031031681

U2 - 10.1016/S0960-894X(96)00610-5

DO - 10.1016/S0960-894X(96)00610-5

M3 - Article

AN - SCOPUS:0031031681

SN - 0960-894X

VL - 7

SP - 209

EP - 212

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique

Abstract

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