TY - JOUR
T1 - Dietary intake of copper and gastric cancer
T2 - a pooled analysis within the Stomach cancer Pooling (StoP) Project
AU - Sassano, Michele
AU - Collatuzzo, Giulia
AU - Seyyedsalehi, Monireh Sadat
AU - Pelucchi, Claudio
AU - Bonzi, Rossella
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Lunet, Nuno
AU - Morais, Samantha
AU - López-Carrillo, Lizbeth
AU - Malekzadeh, Reza
AU - Pakseresht, Mohammadreza
AU - López-Cervantes, Malaquias
AU - Ward, Mary H.
AU - Camargo, Maria Constanza
AU - Curado, Maria Paula
AU - Vioque, Jesùs
AU - Zhang, Zuo Feng
AU - Boccia, Stefania
AU - Negri, Eva
AU - La Vecchia, Carlo
AU - Boffetta, Paolo
N1 - Publisher Copyright:
© The Author(s) 2024; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Background: Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC. Methods: Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial. Results: The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend ¼ 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes. Conclusions: The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.
AB - Background: Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC. Methods: Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial. Results: The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend ¼ 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes. Conclusions: The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.
KW - Gastric cancer
KW - case-control
KW - consortium
KW - copper
KW - diet
KW - pooled analysis
UR - https://www.scopus.com/pages/publications/85191634958
U2 - 10.1093/ije/dyae059
DO - 10.1093/ije/dyae059
M3 - Article
C2 - 38670544
AN - SCOPUS:85191634958
SN - 0300-5771
VL - 53
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 3
M1 - dyae059
ER -