TY - JOUR
T1 - Dietary intake of vitamin C and gastric cancer
T2 - a pooled analysis within the Stomach cancer Pooling (StoP) Project
AU - Sassano, Michele
AU - Seyyedsalehi, Monireh Sadat
AU - Collatuzzo, Giulia
AU - Pelucchi, Claudio
AU - Bonzi, Rossella
AU - Ferraroni, Monica
AU - Palli, Domenico
AU - Yu, Guo Pei
AU - Zhang, Zuo Feng
AU - López-Carrillo, Lizbeth
AU - Lunet, Nuno
AU - Morais, Samantha
AU - Zaridze, David
AU - Maximovich, Dmitry
AU - Martín, Vicente
AU - Castano-Vinyals, Gemma
AU - Vioque, Jesús
AU - González-Palacios, Sandra
AU - Ward, Mary H.
AU - Malekzadeh, Reza
AU - Pakseresht, Mohammadreza
AU - Hernández-Ramirez, Raul Ulises
AU - López-Cervantes, Malaquias
AU - Negri, Eva
AU - Turati, Federica
AU - Rabkin, Charles S.
AU - Tsugane, Shoichiro
AU - Hidaka, Akihisa
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Camargo, M. Constanza
AU - Curado, Maria Paula
AU - Boccia, Stefania
AU - La Vecchia, Carlo
AU - Boffetta, Paolo
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Background: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. Methods: Fourteen case–control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose–response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials. Results: Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose–response analysis showed decreasing ORs of GC up to 150–200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0. Conclusions: The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).
AB - Background: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. Methods: Fourteen case–control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose–response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials. Results: Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose–response analysis showed decreasing ORs of GC up to 150–200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0. Conclusions: The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).
KW - Case–control
KW - Consortium
KW - Diet
KW - Gastric cancer
KW - Pooled analysis
KW - Vitamin C
UR - https://www.scopus.com/pages/publications/85186623658
U2 - 10.1007/s10120-024-01476-8
DO - 10.1007/s10120-024-01476-8
M3 - Article
C2 - 38436761
AN - SCOPUS:85186623658
SN - 1436-3291
VL - 27
SP - 461
EP - 472
JO - Gastric Cancer
JF - Gastric Cancer
IS - 3
ER -