TY - JOUR
T1 - Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
AU - Santucci, Claudia
AU - Natale, Arianna
AU - Pelucchi, Claudio
AU - Bonzi, Rossella
AU - Lunet, Nuno
AU - Morais, Samantha
AU - Vioque, Jesús
AU - González-Palacios, Sandra
AU - Aragonés, Nuria
AU - Castaño-Vinyals, Gemma
AU - Malekzadeh, Reza
AU - Pakseresht, Mohammadreza
AU - Negri, Eva
AU - Boffetta, Paolo
AU - Camargo, M. Constanza
AU - Curado, Maria Paula
AU - Zhang, Zuo Feng
AU - Boccia, Stefania
AU - La Vecchia, Carlo
AU - Rossi, Marta
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/9
Y1 - 2025/9
N2 - Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case–control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models. Results: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80–1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption. Conclusions: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.
AB - Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk. Methods: Five case–control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models. Results: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80–1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption. Conclusions: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.
KW - Dietary vitamin D
KW - Epidemiology
KW - Gastric cancer
KW - Pooled analysis
UR - https://www.scopus.com/pages/publications/105014930924
U2 - 10.1007/s00394-025-03768-w
DO - 10.1007/s00394-025-03768-w
M3 - Article
C2 - 40886187
AN - SCOPUS:105014930924
SN - 1436-6207
VL - 64
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 6
M1 - 269
ER -