Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation

F. John Gennari; Roger Barton; Ernest Benjamin; Thomas A. Paluch; David R. Gentili; Thomas J. Iberti; Douglas C. Johnson; David M. Systrom; Joseph A. Chazan; Max Harry Weil; Eric C. Rackow; Jay L. Falk; Martin I. Griffel; Arnold S. Relman

doi:10.1056/NEJM198612183152519

Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation

F. John Gennari
, Roger Barton
, Ernest Benjamin
, Thomas A. Paluch
, David R. Gentili
, Thomas J. Iberti
, Douglas C. Johnson
, David M. Systrom
, Joseph A. Chazan
, Max Harry Weil
, Eric C. Rackow
, Jay L. Falk
, Martin I. Griffel
, Arnold S. Relman

Anesthesiology

University of Vermont
University of Edinburgh
Icahn School of Medicine at Mount Sinai
Massachusetts General Hospital
Rhode Island Hospital
University of Health Sciences, The Chicago Medical School

Research output: Contribution to journal › Letter › peer-review

10 Scopus citations

Abstract

To the Editor: The marked elevation in mixed venous partial pressure of carbon dioxide (PCO₂) found during cardiopulmonary resuscitation by Weil and coworkers (July 17 issue)¹ is an intriguing new observation, and clearly requires further studies to delineate its clinical importance. The authors and your accompanying editorial² both offer explanations for the high PCO₂. I am perplexed, however, because no one even raised for consideration what seems to be the most likely cause — abrupt restoration of oxidative metabolism and a resultant surge of carbon dioxide production as tissue oxygen delivery returns. More than 90 percent.

Original language	English
Pages (from-to)	1616-1618
Number of pages	3
Journal	New England Journal of Medicine
Volume	315
Issue number	25
DOIs	https://doi.org/10.1056/NEJM198612183152519
State	Published - Dec 18 1986

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Gennari, F. J., Barton, R., Benjamin, E., Paluch, T. A., Gentili, D. R., Iberti, T. J., Johnson, D. C., Systrom, D. M., Chazan, J. A., Weil, M. H., Rackow, E. C., Falk, J. L., Griffel, M. I., & Relman, A. S. (1986). Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation. New England Journal of Medicine, 315(25), 1616-1618. https://doi.org/10.1056/NEJM198612183152519

@article{b287e196087f4f09a91e3e5125a0bc95,

title = "Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation",

abstract = "To the Editor: The marked elevation in mixed venous partial pressure of carbon dioxide (PCO2) found during cardiopulmonary resuscitation by Weil and coworkers (July 17 issue)1 is an intriguing new observation, and clearly requires further studies to delineate its clinical importance. The authors and your accompanying editorial2 both offer explanations for the high PCO2. I am perplexed, however, because no one even raised for consideration what seems to be the most likely cause — abrupt restoration of oxidative metabolism and a resultant surge of carbon dioxide production as tissue oxygen delivery returns. More than 90 percent.",

author = "Gennari, \{F. John\} and Roger Barton and Ernest Benjamin and Paluch, \{Thomas A.\} and Gentili, \{David R.\} and Iberti, \{Thomas J.\} and Johnson, \{Douglas C.\} and Systrom, \{David M.\} and Chazan, \{Joseph A.\} and Weil, \{Max Harry\} and Rackow, \{Eric C.\} and Falk, \{Jay L.\} and Griffel, \{Martin I.\} and Relman, \{Arnold S.\}",

year = "1986",

month = dec,

day = "18",

doi = "10.1056/NEJM198612183152519",

language = "English",

volume = "315",

pages = "1616--1618",

journal = "New England Journal of Medicine",

issn = "0028-4793",

number = "25",

}

Gennari, FJ, Barton, R, Benjamin, E, Paluch, TA, Gentili, DR, Iberti, TJ, Johnson, DC, Systrom, DM, Chazan, JA, Weil, MH, Rackow, EC, Falk, JL, Griffel, MI & Relman, AS 1986, 'Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation', New England Journal of Medicine, vol. 315, no. 25, pp. 1616-1618. https://doi.org/10.1056/NEJM198612183152519

TY - JOUR

T1 - Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation

AU - Gennari, F. John

AU - Barton, Roger

AU - Benjamin, Ernest

AU - Paluch, Thomas A.

AU - Gentili, David R.

AU - Iberti, Thomas J.

AU - Johnson, Douglas C.

AU - Systrom, David M.

AU - Chazan, Joseph A.

AU - Weil, Max Harry

AU - Rackow, Eric C.

AU - Falk, Jay L.

AU - Griffel, Martin I.

AU - Relman, Arnold S.

PY - 1986/12/18

Y1 - 1986/12/18

N2 - To the Editor: The marked elevation in mixed venous partial pressure of carbon dioxide (PCO2) found during cardiopulmonary resuscitation by Weil and coworkers (July 17 issue)1 is an intriguing new observation, and clearly requires further studies to delineate its clinical importance. The authors and your accompanying editorial2 both offer explanations for the high PCO2. I am perplexed, however, because no one even raised for consideration what seems to be the most likely cause — abrupt restoration of oxidative metabolism and a resultant surge of carbon dioxide production as tissue oxygen delivery returns. More than 90 percent.

AB - To the Editor: The marked elevation in mixed venous partial pressure of carbon dioxide (PCO2) found during cardiopulmonary resuscitation by Weil and coworkers (July 17 issue)1 is an intriguing new observation, and clearly requires further studies to delineate its clinical importance. The authors and your accompanying editorial2 both offer explanations for the high PCO2. I am perplexed, however, because no one even raised for consideration what seems to be the most likely cause — abrupt restoration of oxidative metabolism and a resultant surge of carbon dioxide production as tissue oxygen delivery returns. More than 90 percent.

UR - https://www.scopus.com/pages/publications/0022910313

U2 - 10.1056/NEJM198612183152519

DO - 10.1056/NEJM198612183152519

M3 - Letter

C2 - 3097546

AN - SCOPUS:0022910313

SN - 0028-4793

VL - 315

SP - 1616

EP - 1618

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 25

ER -

Difference in Acid-Base State between Venous and Arterial Blood during Cardiopulmonary Resuscitation

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