@inproceedings{fcb4d0b35e2d4d3e8950d57cf5aec67b,
title = "Directing cell migration by electrospun fibers",
abstract = "In this study, aligned poly (methyl methacrylate) (PMMA) fibers designed as guidance structure were produced by electrospinning and tested in en masse cell migration assays. We have shown that migration of fibroblasts on the planar surface results in a radial outward trajectory, and a spatially dependent velocity distribution decreases exponentially in time towards the single cell value. If the cells are plated on the surface of aligned electrospun fibers above 1 micro in diameter, they become polarized along the fiber. The velocity of the cells on the fibrous scaffold is lower than that on the planar surface. Contrary to expectations, the rate at which cells migrate within the construct is mostly dependent on the orientation of the fibers and nearly independent on the size of the holes. These results indicate that electrospun fibers can be used to regulate cell migration and therefore provide controlled cell delivery systems.",
keywords = "Cell migration, Electrospinning, Polymer fibers, Wound healing",
author = "Y. Liu and A. Franco and L. Huang and R. Clark and M. Rafailovich",
year = "2010",
language = "English",
isbn = "9781439834015",
series = "Nanotechnology 2010: Advanced Materials, CNTs, Particles, Films and Composites - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010",
pages = "881--884",
booktitle = "Nanotechnology 2010",
note = "Nanotechnology 2010: Advanced Materials, CNTs, Particles, Films and Composites - 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 ; Conference date: 21-06-2010 Through 24-06-2010",
}