Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology

Aleksandra Klimas; Yiyang Wu; Christina M. Ambrosi; Jinzhu Yu; John C. Williams; Harold Bien; Gholson J. Lyon; Emilia Entcheva

doi:10.1364/FIO.2016.FF3A.3

Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology

Aleksandra Klimas
, Yiyang Wu
, Christina M. Ambrosi
, Jinzhu Yu
, John C. Williams
, Harold Bien
, Gholson J. Lyon
, Emilia Entcheva

Medical Oncology

George Washington University
Stony Brook University
Cold Spring Harbor Laboratory

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

We present an all-optical high-throughput system for phenotyping and monitoring iPSC-CMs, with capabilities for performing personalized cardiotoxicity screening. We demonstrate the system's utility for characterizing a new disease model in iPSC-CMs.

Original language	English
Title of host publication	Frontiers in Optics, FiO 2016
Publisher	Optica Publishing Group (formerly OSA)
ISBN (Print)	9781943580194
DOIs	https://doi.org/10.1364/FIO.2016.FF3A.3
State	Published - 2016
Event	Frontiers in Optics, FiO 2016 - Rochester, United States Duration: Oct 17 2016 → Oct 21 2016

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Electronic)	2162-2701

Conference

Conference	Frontiers in Optics, FiO 2016
Country/Territory	United States
City	Rochester
Period	10/17/16 → 10/21/16

Access to Document

10.1364/FIO.2016.FF3A.3

Cite this

Klimas, A., Wu, Y., Ambrosi, C. M., Yu, J., Williams, J. C., Bien, H., Lyon, G. J., & Entcheva, E. (2016). Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology. In Frontiers in Optics, FiO 2016 (Optics InfoBase Conference Papers). Optica Publishing Group (formerly OSA). https://doi.org/10.1364/FIO.2016.FF3A.3

@inproceedings{e3988ce928304b6887051114130ccbd9,

title = "Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology",

abstract = "We present an all-optical high-throughput system for phenotyping and monitoring iPSC-CMs, with capabilities for performing personalized cardiotoxicity screening. We demonstrate the system's utility for characterizing a new disease model in iPSC-CMs.",

author = "Aleksandra Klimas and Yiyang Wu and Ambrosi, \{Christina M.\} and Jinzhu Yu and Williams, \{John C.\} and Harold Bien and Lyon, \{Gholson J.\} and Emilia Entcheva",

note = "Publisher Copyright: {\textcopyright} OSA 2016.; Frontiers in Optics, FiO 2016 ; Conference date: 17-10-2016 Through 21-10-2016",

year = "2016",

doi = "10.1364/FIO.2016.FF3A.3",

language = "English",

isbn = "9781943580194",

series = "Optics InfoBase Conference Papers",

publisher = "Optica Publishing Group (formerly OSA)",

booktitle = "Frontiers in Optics, FiO 2016",

}

Klimas, A, Wu, Y, Ambrosi, CM, Yu, J, Williams, JC, Bien, H, Lyon, GJ & Entcheva, E 2016, Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology. in Frontiers in Optics, FiO 2016. Optics InfoBase Conference Papers, Optica Publishing Group (formerly OSA), Frontiers in Optics, FiO 2016, Rochester, United States, 10/17/16. https://doi.org/10.1364/FIO.2016.FF3A.3

Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology. / Klimas, Aleksandra; Wu, Yiyang; Ambrosi, Christina M. et al.
Frontiers in Optics, FiO 2016. Optica Publishing Group (formerly OSA), 2016. (Optics InfoBase Conference Papers).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology

AU - Klimas, Aleksandra

AU - Wu, Yiyang

AU - Ambrosi, Christina M.

AU - Yu, Jinzhu

AU - Williams, John C.

AU - Bien, Harold

AU - Lyon, Gholson J.

AU - Entcheva, Emilia

PY - 2016

Y1 - 2016

N2 - We present an all-optical high-throughput system for phenotyping and monitoring iPSC-CMs, with capabilities for performing personalized cardiotoxicity screening. We demonstrate the system's utility for characterizing a new disease model in iPSC-CMs.

AB - We present an all-optical high-throughput system for phenotyping and monitoring iPSC-CMs, with capabilities for performing personalized cardiotoxicity screening. We demonstrate the system's utility for characterizing a new disease model in iPSC-CMs.

UR - https://www.scopus.com/pages/publications/85165755235

U2 - 10.1364/FIO.2016.FF3A.3

DO - 10.1364/FIO.2016.FF3A.3

M3 - Conference contribution

AN - SCOPUS:85165755235

SN - 9781943580194

T3 - Optics InfoBase Conference Papers

BT - Frontiers in Optics, FiO 2016

PB - Optica Publishing Group (formerly OSA)

T2 - Frontiers in Optics, FiO 2016

Y2 - 17 October 2016 through 21 October 2016

ER -

Disease modeling in human induced pluripotent stem cell derived cardiomyocytes using high-throughput all- optical dynamic cardiac electrophysiology

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