Abstract
Canonical Wnt/β-catenin signaling is crucial during embryonic development. Upon Wnt stimulation, Dishevelled proteins relay the signal from upstream Frizzled receptors to downstream effectors. By using affinity purification followed by ion-trap mass spectrometry we identified K-homology splicing regulator protein (KSRP) as a novel Dishevelled-interacting protein. We show that KSRP negatively regulates Wnt/β-catenin signaling at the level of post-transcriptional CTNNB1 (β-catenin) mRNA stability. Thus, Dishevelled-KSRP complex operates in Wnt regulation of β-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability.
| Original language | English |
|---|---|
| Pages (from-to) | 1352-1362 |
| Number of pages | 11 |
| Journal | Journal of Cell Science |
| Volume | 123 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 15 2010 |
Keywords
- β-catenin
- Canonical pathway
- Dvl
- Frizzled
- K-homology splicing regulatory protein
- KSRP
- Lef/Tcf
- Primitive endoderm
- RNA decay
- Wnt
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