Abstract
Salivary cortisol and alpha-amylase are known to have distinctive diurnal profiles. However, little is known about systematic changes in these biomarkers across the adult lifespan. In a study of 185 participants (aged 20-81 years), time-stamped salivary cortisol and alpha-amylase were collected 7 times/day over 10 days. Samples were taken upon waking, 30. min later, and then approximately every 3. h until 9. pm. Multilevel models showed that older age was associated with increased daily cortisol secretion as indicated by greater area under the curve, attenuated wake-evening slopes, and more pronounced cortisol awakening responses. Further, older age was related to greater daily alpha-amylase output and attenuated wake-evening slopes. No age differences were observed regarding the alpha-amylase awakening response. Our findings may contribute to a better understanding of age-related differences in functioning of stress-related systems.
| Original language | English |
|---|---|
| Pages (from-to) | 3167-3171 |
| Number of pages | 5 |
| Journal | Psychoneuroendocrinology |
| Volume | 38 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2013 |
Keywords
- Aging
- Cortisol
- Lifespan
- Salivary alpha-amylase
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