DNA-binding by Ig-fold proteins

M. J. Rudolph; J. P. Gergen

doi:10.1038/87531

DNA-binding by Ig-fold proteins

M. J. Rudolph
, J. P. Gergen

Biochemistry and Cell Biology

Stony Brook University

Research output: Contribution to journal › Short survey › peer-review

38 Scopus citations

Abstract

Recent structures of the Runx1-CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop regions accounts for the diversity of DNA sequences recognized by Ig-fold proteins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.

Original language	English
Pages (from-to)	384-386
Number of pages	3
Journal	Nature Structural Biology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/87531
State	Published - 2001

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abstract = "Recent structures of the Runx1-CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop regions accounts for the diversity of DNA sequences recognized by Ig-fold proteins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.",

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AU - Gergen, J. P.

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AB - Recent structures of the Runx1-CBFβ heterodimer bound to DNA brings to six the number of characterized eukaryotic transcription factor families that use an immunoglobulin (Ig) fold to bind to DNA. Variation in the loop regions accounts for the diversity of DNA sequences recognized by Ig-fold proteins, but there are recurring themes in the interactions made by specific loop regions and how these interactions are regulated.

UR - https://www.scopus.com/pages/publications/0035037038

U2 - 10.1038/87531

DO - 10.1038/87531

M3 - Short survey

C2 - 11323707

AN - SCOPUS:0035037038

SN - 1072-8368

VL - 8

SP - 384

EP - 386

JO - Nature Structural Biology

JF - Nature Structural Biology

IS - 5

ER -

DNA-binding by Ig-fold proteins

Abstract

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