DNA sequencing by multiple capillaries that form a waveguide

Harbans S. Dhadwal; Mark A. Quesada; F. William Studier

doi:10.1117/12.273541

DNA sequencing by multiple capillaries that form a waveguide

Harbans S. Dhadwal
, Mark A. Quesada
, F. William Studier

Electrical Engineering

Brookhaven National Laboratory

Research output: Contribution to journal › Conference article › peer-review

Abstract

A 12-capillary prototype electrophoresis system for DNA sequencing has been constructed. Laser illumination is introduced into an optical waveguide that is formed by an array of individual capillaries that serve both as the optical elements of the periodic array and as the channels containing sieving media for electrophoresis. A theoretical framework and experimental data will be presented to illustrate the viability of this approach.

Original language	English
Pages (from-to)	149-162
Number of pages	14
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2980
DOIs	https://doi.org/10.1117/12.273541
State	Published - 1997
Event	Advances in Fluorescence Sensing Technology III - San Jose, CA, United States Duration: Feb 9 1997 → Feb 9 1997

Keywords

Capillary electrophoresis
DNA sequencing
Fiber optics
Fluorescence
Lasers

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10.1117/12.273541

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title = "DNA sequencing by multiple capillaries that form a waveguide",

abstract = "A 12-capillary prototype electrophoresis system for DNA sequencing has been constructed. Laser illumination is introduced into an optical waveguide that is formed by an array of individual capillaries that serve both as the optical elements of the periodic array and as the channels containing sieving media for electrophoresis. A theoretical framework and experimental data will be presented to illustrate the viability of this approach.",

keywords = "Capillary electrophoresis, DNA sequencing, Fiber optics, Fluorescence, Lasers",

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year = "1997",

doi = "10.1117/12.273541",

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pages = "149--162",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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AU - Dhadwal, Harbans S.

AU - Quesada, Mark A.

AU - Studier, F. William

PY - 1997

Y1 - 1997

N2 - A 12-capillary prototype electrophoresis system for DNA sequencing has been constructed. Laser illumination is introduced into an optical waveguide that is formed by an array of individual capillaries that serve both as the optical elements of the periodic array and as the channels containing sieving media for electrophoresis. A theoretical framework and experimental data will be presented to illustrate the viability of this approach.

AB - A 12-capillary prototype electrophoresis system for DNA sequencing has been constructed. Laser illumination is introduced into an optical waveguide that is formed by an array of individual capillaries that serve both as the optical elements of the periodic array and as the channels containing sieving media for electrophoresis. A theoretical framework and experimental data will be presented to illustrate the viability of this approach.

KW - Capillary electrophoresis

KW - DNA sequencing

KW - Fiber optics

KW - Fluorescence

KW - Lasers

UR - https://www.scopus.com/pages/publications/58049171783

U2 - 10.1117/12.273541

DO - 10.1117/12.273541

M3 - Conference article

AN - SCOPUS:58049171783

SN - 0277-786X

VL - 2980

SP - 149

EP - 162

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Advances in Fluorescence Sensing Technology III

Y2 - 9 February 1997 through 9 February 1997

ER -

DNA sequencing by multiple capillaries that form a waveguide

Abstract

Keywords

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