Documentation of IgA1 and IgA2 Antisperm Antibodies Within Seminal Fluid

RICHARD A. BRONSON; GEORGE W. COOPER

doi:10.1111/j.1600-0897.1988.tb00225.x

Documentation of IgA₁ and IgA₂ Antisperm Antibodies Within Seminal Fluid

RICHARD A. BRONSON
, GEORGE W. COOPER

Obstetrics and Gynecology

Northwell Health System

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

ABSTRACT: Antisperm antibodies of the IgA class, when bound to sperm, impair the sperm's ability to penetrate cervical mucus. IgA proteases offer a potential treatment of autoimmunity to spermatozoa in infertile men by enzymatically degrading immunoglobulins on the sperm surface. As IgA₁ but not IgA₂ is cleaved by IgA proteases, we determined through use of IgA subclass‐specific monoclonal antibodies the presence and relative proportions of antisperm IgA₁ and IgA₂ in seminal fluid. This ratio varies substantially between men, perhaps reflecting differences in the etiology of autoimmunity to sperm. 1988 Munksgaard

Original language	English
Pages (from-to)	7-10
Number of pages	4
Journal	American Journal of Reproductive Immunology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0897.1988.tb00225.x
State	Published - Sep 1988

Keywords

autoimmunity
IgA sublcasses
Protease

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10.1111/j.1600-0897.1988.tb00225.x

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abstract = "ABSTRACT: Antisperm antibodies of the IgA class, when bound to sperm, impair the sperm's ability to penetrate cervical mucus. IgA proteases offer a potential treatment of autoimmunity to spermatozoa in infertile men by enzymatically degrading immunoglobulins on the sperm surface. As IgA1 but not IgA2 is cleaved by IgA proteases, we determined through use of IgA subclass‐specific monoclonal antibodies the presence and relative proportions of antisperm IgA1 and IgA2 in seminal fluid. This ratio varies substantially between men, perhaps reflecting differences in the etiology of autoimmunity to sperm. 1988 Munksgaard",

keywords = "autoimmunity, IgA sublcasses, Protease",

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year = "1988",

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AU - COOPER, GEORGE W.

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N2 - ABSTRACT: Antisperm antibodies of the IgA class, when bound to sperm, impair the sperm's ability to penetrate cervical mucus. IgA proteases offer a potential treatment of autoimmunity to spermatozoa in infertile men by enzymatically degrading immunoglobulins on the sperm surface. As IgA1 but not IgA2 is cleaved by IgA proteases, we determined through use of IgA subclass‐specific monoclonal antibodies the presence and relative proportions of antisperm IgA1 and IgA2 in seminal fluid. This ratio varies substantially between men, perhaps reflecting differences in the etiology of autoimmunity to sperm. 1988 Munksgaard

AB - ABSTRACT: Antisperm antibodies of the IgA class, when bound to sperm, impair the sperm's ability to penetrate cervical mucus. IgA proteases offer a potential treatment of autoimmunity to spermatozoa in infertile men by enzymatically degrading immunoglobulins on the sperm surface. As IgA1 but not IgA2 is cleaved by IgA proteases, we determined through use of IgA subclass‐specific monoclonal antibodies the presence and relative proportions of antisperm IgA1 and IgA2 in seminal fluid. This ratio varies substantially between men, perhaps reflecting differences in the etiology of autoimmunity to sperm. 1988 Munksgaard

KW - autoimmunity

KW - IgA sublcasses

KW - Protease

UR - https://www.scopus.com/pages/publications/0023823248

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JF - American Journal of Reproductive Immunology

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ER -

Documentation of IgA₁ and IgA₂ Antisperm Antibodies Within Seminal Fluid

Abstract

Keywords

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