Dominant inhibition of intercellular communication by two chimeric connexins

Jefferey A. Goliger; Roberto Bruzzone; Thomas W. White; David L. Paul

doi:10.1111/j.1440-1681.1996.tb01170.x

Dominant inhibition of intercellular communication by two chimeric connexins

Jefferey A. Goliger
, Roberto Bruzzone
, Thomas W. White
, David L. Paul

Physiology and Biophysics

Harvard University
Institut Pasteur Paris

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.

Original language	English
Pages (from-to)	1062-1067
Number of pages	6
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1111/j.1440-1681.1996.tb01170.x
State	Published - 1996

Keywords

Dominant-negative mutation
Gap junction
Intercellulr communication

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10.1111/j.1440-1681.1996.tb01170.x

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title = "Dominant inhibition of intercellular communication by two chimeric connexins",

abstract = "1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.",

keywords = "Dominant-negative mutation, Gap junction, Intercellulr communication",

author = "Goliger, \{Jefferey A.\} and Roberto Bruzzone and White, \{Thomas W.\} and Paul, \{David L.\}",

year = "1996",

doi = "10.1111/j.1440-1681.1996.tb01170.x",

language = "English",

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T1 - Dominant inhibition of intercellular communication by two chimeric connexins

AU - Goliger, Jefferey A.

AU - Bruzzone, Roberto

AU - White, Thomas W.

AU - Paul, David L.

PY - 1996

Y1 - 1996

N2 - 1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.

AB - 1. The physiological significance of communication through gap junction channels has been difficult to assess because channel activity cannot be experimentally modulated in a specific manner. To address this problem we have constructed chimeric connexins that function as dominant-negative inhibitors of intercellular channel activity.

KW - Dominant-negative mutation

KW - Gap junction

KW - Intercellulr communication

UR - https://www.scopus.com/pages/publications/0030477150

U2 - 10.1111/j.1440-1681.1996.tb01170.x

DO - 10.1111/j.1440-1681.1996.tb01170.x

M3 - Article

C2 - 8977161

AN - SCOPUS:0030477150

SN - 0305-1870

VL - 23

SP - 1062

EP - 1067

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 12

ER -

Dominant inhibition of intercellular communication by two chimeric connexins

Abstract

Keywords

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